Koenzim F420-0:L-glutamatna ligaza
Koenzim F420-0:L-glutamatna ligaza (EC 6.3.2.31, CofE-AF, MJ0768, CofE) je enzim sa sistematskim imenom L-glutamat:koenzim F420-0 ligaza (formira GDP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Koenzim F420-0:L-glutamatna ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.2.31 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ovaj protein katalizuje the sukcesivnu adiciju dva glutamatna ostatka na kofaktor F420 putem dve nezavisne reakcije.
Reference
uredi- ↑ Li, H., Graupner, M., Xu, H. and White, R.H. (2003). „CofE catalyzes the addition of two glutamates to F420-0 in F420 coenzyme biosynthesis in Methanococcus jannaschii”. Biochemistry 42: 9771-9778. PMID 12911320.
- ↑ Nocek, B., Evdokimova, E., Proudfoot, M., Kudritska, M., Grochowski, L.L., White, R.H., Savchenko, A., Yakunin, A.F., Edwards, A. and Joachimiak, A. (2007). „Structure of an amide bond forming F420:γ-glutamyl ligase from Archaeoglobus fulgidus – a member of a new family of non-ribosomal peptide synthases”. J. Mol. Biol. 372: 456-469. PMID 17669425.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.