Kobalt-prekorin-5B (C1)-metiltransferaza
Kobalt-prekorin-5B (C1)-metiltransferaza (EC 2.1.1.195, kobalt-prekorin-6A sintaza, CbiD (gen)) je enzim sa sistematskim imenom S-adenozil-L-metionin:kobalt-prekorin-5B (C1)-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kobalt-prekorin-5B (C1)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.195 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- kobalt-prekorin-5B + S-adenozil-L-metionin kobalt-prekorin-6A + S-adenozil-L-homocistein
Ovaj enzim katalizuje C-1 metilaciju kobalt-prekorina-5B pri anaerobnoj biosintezi adenozilkobalamina.
Reference uredi
- ↑ Roper, J.M., Raux, E., Brindley, A.A., Schubert, H.L., Gharbia, S.E., Shah, H.N. and Warren, M.J. (2000). „The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway”. J. Biol. Chem. 275: 40316-40323. PMID 11007789.
- ↑ Roessner, C.A., Williams, H.J. and Scott, A.I. (2005). „Genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in Escherichia coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin”. J. Biol. Chem. 280: 16748-16753. PMID 15741157.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.