Karikain
Karikain (EC 3.4.22.30, papajina peptidaza A, papajina peptidaza II, papajina proteinaza, papajina proteinaza III, papajina proteinaza 3, proteinaza omega, papajina proteinaza A, himopapain S, Pp) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Karikain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.30 | ||||||||
| CAS broj | 39307-22-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Hidroliza proteina sa širokom specifičnošću za peptidne veze, slično dejstvu papaina i himopapaina
Ovaj enzim je izolovan iz papajinog ploda, Carica papaya.
Reference uredi
- ↑ Schack, P. (1967). „Fractionation of proteolytic enzymes of dried papaya latex. Isolation and preliminary characterization of a new proteolytic enzyme”. C. R. Trav. Carlesberg 36: 67-83. PMID 6043136.
- ↑ Robinson, G.W. (1975). „Isolation and characterization of papaya peptidase A from commercial chymopapain”. Biochemistry 16: 3695-3700. PMID 240390.
- ↑ Polgár, L. (1984). „Problems of classification of papaya latex proteinases”. Biochem. J. 221: 555-556. PMID 6383350.
- ↑ Brocklehurst, K., Salih, E., McKee, R. and Smith, H. (1985). „Fresh non-fruit latex of Carica papaya contains papain, multiple forms of chymopapain A and papaya proteinase”. Biochem. J. 228: 525-527. PMID 4015629.
- ↑ Zucker, S., Buttle, D.J., Nicklin, M.J.H. and Barrett, A.J. (1985). „Proteolytic activities of papain, chymopapain and papaya proteinase III”. Biochim. Biophys. Acta 828: 196-204. PMID 3919769.
- ↑ Dubois, T., Kleinschmidt, T., Schnek, A.G., Looze, Y. and Braunitzer, G. (1988). „The thiol proteinases from the latex of Carica papaya L. II. The primary structure of proteinase”. Biol. Chem. Hoppe-Seyler 369: 741-754. PMID 3063283.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.