Kanabigerol

Kanabigerol
(IUPAC) ime
	2-[(2E)-3,7-dimetilokta-2,6-dienil]-5-pentil-benzen-1,3-diol
Klinički podaci
Identifikatori
CAS broj	25654-31-3
ATC kod	nije dodeljen
PubChem	5315659
ChemSpider	4474921
ChEMBL	CHEMBL497318
Hemijski podaci
Formula	C21H32O2
Mol. masa	316,48 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C21H32O2/c1-5-6-7-11-18-14-20(22)19(21(23)15-18)13-12-17(4)10-8-9-16(2)3/h9,12,14-15,22-23H,5-8,10-11,13H2,1-4H3/b17-12+ ; Key: QXACEHWTBCFNSA-SFQUDFHCSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Kanabigerol (CBG) je kanabinoid iz Cannabis roda biljki koji nije psihoaktivan. Kanabigerol je prisutan u visokim koncentracijama u industrijskoj konoplji.

Kanabigerol deluje sa visokim afinitetom kao agonist α₂-adrenergičkog receptora, umereni antagonist 5-HT_1A receptora, i slab antagonist CB₁ receptora.^[5] It also binds to the CB₂ receptor, but whether it acts as an agonist or antagonist at this site is unknown.^[5]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ ^5,0 ^5,1 Cascio MG, Gauson LA, Stevenson LA, Ross RA, Pertwee R (December 2009). „Evidence that the plant cannabinoid cannabigerol is a highly potent alpha(2)-adrenoceptor agonist and moderately potent 5HT receptor antagonist”. British Journal of Pharmacology 159 (1): 129–141. DOI:10.1111/j.1476-5381.2009.00515.x. PMC 2823359. PMID 20002104.

Vidi još uredi

Kanabinoid

Šablon:Kanabinoidi

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid20002104-5] 5,0 ^5,1 Cascio MG, Gauson LA, Stevenson LA, Ross RA, Pertwee R (December 2009). „Evidence that the plant cannabinoid cannabigerol is a highly potent alpha(2)-adrenoceptor agonist and moderately potent 5HT receptor antagonist”. British Journal of Pharmacology 159 (1): 129–141. DOI:10.1111/j.1476-5381.2009.00515.x. PMC 2823359. PMID 20002104.

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