Isetionska kiselina

Isetionska kiselina
	2-hidroksietanesulfonska kiselina
Identifikacija
CAS registarski broj	107-36-8
PubChem	7866
ChemSpider	7578
KEGG	C05123
Jmol-3D slike	Slika 1
SMILES
	O=S(=O)(O)CCO
InChI
	InChI=1S/C2H6O4S/c3-1-2-7(4,5)6/h3H,1-2H2,(H,4,5,6) ; Kod: SUMDYPCJJOFFON-UHFFFAOYSA-N InChI=1/C2H6O4S/c3-1-2-7(4,5)6/h3H,1-2H2,(H,4,5,6); Kod: SUMDYPCJJOFFON-UHFFFAOYAO
Svojstva
Molekulska formula	C2H6O4S
Molarna masa	126,13 g/mol
Gustina	1,63 g/cm3
Tačka topljenja	191-194 °C
Tačka ključanja	100 °C, 373 K, 212 °F
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Isetionska kiselina je sulfonska kiselina sa kratkim alkilnim lancem i terminalnom hidroksilnom grupom. Ona je tečnost rastvorna u vodi koja se koristi u proizvodnji blagih, biorazgradivih i visoko penećih anjonskih surfikanata. Oni omogućavaju nežno čišćenje i mek osećaj kože.^[5]

Sintetička isetionska kiselina se dobija reakcijom etilen oksida sa rastvorenim natrijum bisulfitom, i koristi se u industrijskoj proizvodnji taurina.^[6]

Biološki značaj uredi

Nedavna ispitivanja na isečcima srca pasa sugerišu da srčano tkivo možda ima sposobnost konverovanja taurina u isetionsku kiselinu. Dodatni eksperimenti su demonstrirali da ovo tkivo može da sintetiše taurin iz cistina.^[7]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ „Chemical land 21”. Isethionic acid. Pristupljeno 16. 9. 2005.
↑ Kurt Kosswig (2000 doi=10.1002/14356007.a25_503). „Sulfonic Acids, Aliphatic”. Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH.
↑ W.O Read and J.D.Welty (1961). „Synthesis of Taurine and Isethionic Acid by Dog Heart Slices”. The Journal of Biological Chemistry 237: 1521–1522.

Literatura uredi

Kurt Kosswig (2000 doi=10.1002/14356007.a25_503). „Sulfonic Acids, Aliphatic”. Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] „Chemical land 21”. Isethionic acid. Pristupljeno 16. 9. 2005.

[6] Kurt Kosswig (2000 doi=10.1002/14356007.a25_503). „Sulfonic Acids, Aliphatic”. Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH.

[7] W.O Read and J.D.Welty (1961). „Synthesis of Taurine and Isethionic Acid by Dog Heart Slices”. The Journal of Biological Chemistry 237: 1521–1522.

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