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Interleukin 9

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Interleukin 9, isto poznat kao IL-9, je citokin (ćelijski signalni molekul) koji pripada grupi interleukina.[1][2]

Interleukin 9
Identifikatori
SimboliIL9; HP40; IL-9; P40
Vanjski IDOMIM: 146931 MGI: 96563 HomoloGene: 492 GeneCards: IL9 Gene
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez357816198
EnsemblENSG00000145839ENSMUSG00000021538
UniProtP15248P15247
Ref. Sekv. (iRNK)NM_000590NM_008373
Ref. Sekv. (protein)NP_000581NP_032399
Lokacija (UCSC)Chr 5:
135.26 - 135.26 Mb		Chr 13:
56.49 - 56.49 Mb
PubMed pretraga[1][2]

Protein kodiran ovim genom je citokin koga proizvode T-ćelije, a posebno CD4+ pomoćne ćelije, koji deluje kao regulator niza hematopoetskih ćelija. Ovaj citokin stimuliše ćelijsku proliferaciju i sprečava apoptozu.[3] On funkcioniše kroz interleukin 9 receptor (IL9R), koji aktivira različite proteine za prenos signala i aktivatore (CTAT). Time se ovaj citokin povezuje sa različitim biološkim procesima. Gen koji kodira ovaj citokin je bio identifikovan kao kandidat gena za astmu. Genetičke studije na mišjim modelima astme su demonstrirali da je ovaj citokin odlučujući faktor u patogenezi bronhijalne hipersenzitivnosti.[1]

Reference uredi

  1. ↑ 1,0 1,1 „Entrez Gene: IL9 interleukin 9”. 
  2. ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
  3. ↑ Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4. 

Literatura uredi

  • Renauld JC, Houssiau F, Louahed J, et al. (1993). „Interleukin-9.”. Adv. Immunol. 54: 79–97. DOI:10.1016/S0065-2776(08)60533-7. PMID 8379467. 
  • Knoops L, Renauld JC (2005). „IL-9 and its receptor: from signal transduction to tumorigenesis.”. Growth Factors 22 (4): 207–15. DOI:10.1080/08977190410001720879. PMID 15621723. 
  • Modi WS, Pollock DD, Mock BA, et al. (1991). „Regional localization of the human glutaminase (GLS) and interleukin-9 (IL9) genes by in situ hybridization.”. Cytogenet. Cell Genet. 57 (2-3): 114–6. DOI:10.1159/000133126. PMID 1680606. 
  • Kelleher K, Bean K, Clark SC, et al. (1991). „Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells.”. Blood 77 (7): 1436–41. PMID 1901233. 
  • Holbrook ST, Ohls RK, Schibler KR, et al. (1991). „Effect of interleukin-9 on clonogenic maturation and cell-cycle status of fetal and adult hematopoietic progenitors.”. Blood 77 (10): 2129–34. PMID 1903074. 
  • Merz H, Houssiau FA, Orscheschek K, et al. (1991). „Interleukin-9 expression in human malignant lymphomas: unique association with Hodgkin's disease and large cell anaplastic lymphoma.”. Blood 78 (5): 1311–7. PMID 1908723. 
  • Renauld JC, Goethals A, Houssiau F, et al. (1990). „Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene.”. J. Immunol. 144 (11): 4235–41. PMID 1971295. 
  • Renauld JC, Goethals A, Houssiau F, et al. (1991). „Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40.”. Cytokine 2 (1): 9–12. DOI:10.1016/1043-4666(90)90037-T. PMID 2129501. 
  • Yang YC, Ricciardi S, Ciarletta A, et al. (1989). „Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40.”. Blood 74 (6): 1880–4. PMID 2508790. 
  • Yin T, Keller SR, Quelle FW, et al. (1995). „Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases.”. J. Biol. Chem. 270 (35): 20497–502. DOI:10.1074/jbc.270.35.20497. PMID 7544789. 
  • Postma DS, Bleecker ER, Amelung PJ, et al. (1995). „Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy.”. N. Engl. J. Med. 333 (14): 894–900. DOI:10.1056/NEJM199510053331402. PMID 7666875. 
  • Le Beau MM, Espinosa R, Neuman WL, et al. (1993). „Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases.”. Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5484–8. DOI:10.1073/pnas.90.12.5484. PMID 8516290. 
  • Demoulin JB, Uyttenhove C, Van Roost E, et al. (1996). „A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9.”. Mol. Cell. Biol. 16 (9): 4710–6. PMID 8756628. 
  • Nicolaides NC, Holroyd KJ, Ewart SL, et al. (1998). „Interleukin 9: a candidate gene for asthma.”. Proc. Natl. Acad. Sci. U.S.A. 94 (24): 13175–80. DOI:10.1073/pnas.94.24.13175. PMID 9371819. 
  • Demoulin JB, Van Roost E, Stevens M, et al. (1999). „Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9.”. J. Biol. Chem. 274 (36): 25855–61. DOI:10.1074/jbc.274.36.25855. PMID 10464327. 
  • Lejeune D, Demoulin JB, Renauld JC (2001). „Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling.”. Biochem. J. 353 (Pt 1): 109–116. DOI:10.1042/0264-6021:3530109. PMID 11115404. 
  • Little FF, Cruikshank WW, Center DM (2001). „Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells.”. Am. J. Respir. Cell Mol. Biol. 25 (3): 347–52. PMID 11588013. 
  • Toda M, Tulic MK, Levitt RC, Hamid Q (2002). „A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma.”. J. Allergy Clin. Immunol. 109 (2): 246–50. DOI:10.1067/mai.2002.121555. PMID 11842292. 
  • Pilette C, Ouadrhiri Y, Van Snick J, et al. (2002). „IL-9 inhibits oxidative burst and TNF-alpha release in lipopolysaccharide-stimulated human monocytes through TGF-beta.”. J. Immunol. 168 (8): 4103–11. PMID 11937570. 

Spoljašnje veze uredi

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