Interleukin 25

Interleukin 25
Identifikatori
Simbol	IL-25
Alt. simboli	IL17E
Entrez	64806
Hugo	13765
OMIM	605658
RefSek	NP_073626
UniProt	Q9H293
Drugi podaci
Lokus	Hrom. 14 q11.2

Interleukin-25 (IL-25) je citokin iz IL-17 citokin familije koga luče tip 2 pomoćne T ćelije (Th2) i mast ćelije.^[1] On je isto poznat kao IL-17E.^[2] IL-25 indukuje produkciju drugih citokina, uključujući IL-4, IL-5 i IL-13 u više tkiva, što stimuliše ekspanziju eosinofila. Ovaj citokin je važan molekul koji kontroliše imunitet stomaka^[3] i bio je impliciran u hroničnu inflamaciju vezanu za gastrointestinalni trakt. Dodatno, IL-25 gen je bio identifikovan na hromozomskom regionu asociranom sa autoimunim bolestima stomaka kao što je upalna bolest creva (IBD), mada nema direktne evidencije koja bi sugerirala da IL-25 igra bilo kakvu ulogu u toj bolesti.^[4]^[5]^[6]

Reference uredi

↑ Ikeda K, Nakajima H, Suzuki K, Kagami S, Hirose K, Suto A, Saito Y, Iwamoto I (May 2003). „Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation”. Blood 101 (9): 3594–6. DOI:10.1182/blood-2002-09-2817. PMID 12511410.
↑ The HGNC site for IL-25^{[mrtav link]}, Pristupljeno 8. 4. 2013.
↑ Owyang AM, Zaph C, Wilson EH, Guild KJ, McClanahan T, Miller HR, Cua DJ, Goldschmidt M, Hunter CA, Kastelein RA, Artis D (April 2006). „Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract”. J. Exp. Med. 203 (4): 843–9. DOI:10.1084/jem.20051496. PMC 1800834. PMID 16606667.
↑ Büning C, Genschel J, Weltrich R, Lochs H, Schmidt H (October 2003). „The interleukin-25 gene located in the inflammatory bowel disease (IBD) 4 region: no association with inflammatory bowel disease”. Eur. J. Immunogenet. 30 (5): 329–33. PMID 14641539.
↑ Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4.
↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

Spoljašnje veze uredi

MeSH Interleukin-25

Wikimedia Commons ima još multimedijalnih datoteka vezanih za: Interleukin 25

[pmid12511410-1] Ikeda K, Nakajima H, Suzuki K, Kagami S, Hirose K, Suto A, Saito Y, Iwamoto I (May 2003). „Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation”. Blood 101 (9): 3594–6. DOI:10.1182/blood-2002-09-2817. PMID 12511410.

[2] The HGNC site for IL-25^{[mrtav link]}, Pristupljeno 8. 4. 2013.

[pmid16606667-3] Owyang AM, Zaph C, Wilson EH, Guild KJ, McClanahan T, Miller HR, Cua DJ, Goldschmidt M, Hunter CA, Kastelein RA, Artis D (April 2006). „Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract”. J. Exp. Med. 203 (4): 843–9. DOI:10.1084/jem.20051496. PMC 1800834. PMID 16606667.

[pmid14641539-4] Büning C, Genschel J, Weltrich R, Lochs H, Schmidt H (October 2003). „The interleukin-25 gene located in the inflammatory bowel disease (IBD) 4 region: no association with inflammatory bowel disease”. Eur. J. Immunogenet. 30 (5): 329–33. PMID 14641539.

[KubyImmunology6th-5] Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4.

[6] Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

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