Indoramin

Indoramin
(IUPAC) ime
	N-{1-[2-(1H-indol-3-il)etil]piperidin-4-il}benzamid
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	26844-12-2
ATC kod	C02CA02
PubChem	33625
ChemSpider	31014
UNII	0Z802HMY7H
KEGG	D04531
ChEMBL	CHEMBL279516
Hemijski podaci
Formula	C22H25N3O
Mol. masa	347,454 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26) ; Key: JXZZEXZZKAWDSP-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Indoramin (baratol) je piperidinski antiadrenergički agens.

On je selektivni antagonist alFa-1 adrenoceptora^[6] sa direktnom miokardijalnim depresivnim dejstvom; te stoga ne proizvodi refleks tahikardije.

Indoramin se često sintetiše počevši od triptofola.^[7]

ReferenceUredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Pierce V, Shepperson NB, Todd MH, Waterfall JF (February 1986). „Investigation into the cardioregulatory properties of the alpha 1-adrenoceptor blocker indoramin”. Br. J. Pharmacol. 87 (2): 433–441. PMC 1916533. PMID 3955309.
↑ Ullman's encyclopedia of Industrial Chemistry, Sixth Edition, 2002.

Spoljašnje vezeUredi

	Portal Medicina
	Portal Hemija

Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid3955309-6] Pierce V, Shepperson NB, Todd MH, Waterfall JF (February 1986). „Investigation into the cardioregulatory properties of the alpha 1-adrenoceptor blocker indoramin”. Br. J. Pharmacol. 87 (2): 433–441. PMC 1916533. PMID 3955309.

[7] Ullman's encyclopedia of Industrial Chemistry, Sixth Edition, 2002.

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