Histon-lizin N-metiltransferaza
Histon-lizin N-metiltransferaza (EC 2.1.1.43, proteinska metilaza III, proteinska metilaza 3, proteinska (lizin) metiltransferaza, proteinska metiltransferaza II, protein-lizinska N-metiltransferaza, histon H1-specifični S-adenozilmetionin:protein-lizin N-metiltransferaza, S-adenozil-L-metionin:histon-L-lizin 6-N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:histon-L-lizin N6-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Histon-lizin N-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.43 | ||||||||
| CAS broj | 2613530 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + histon L-lizin S-adenozil-L-homocistein + histon N6-metil-L-lizin
Ovaj enzim pripada grup metilacionih proteina.
Reference uredi
- ↑ Paik, W.K. and Kim, S. (1970). „Solubilization and partial purification of protein methylase 3 from calf thymus nuclei”. J. Biol. Chem. 245: 6010-6015. PMID 5484460.
- ↑ Venkatesan, M. and McManus, I.R. (1979). „Partial purification and characterization of a protein lysine methyltransferase from plasmodia of Physarum polycephalum”. Biochemistry 18: 5365-5371. PMID 391266.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.