Hijaluronatna lijaza
Hijaluronatna lijaza (EC 4.2.2.1, hijaluronidaza, glukuronaglikozaminoglikanska lijaza, mukinaza) je enzim sa sistematskim imenom hialuronat lijaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hijaluronatna lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.2.1 | ||||||||
| CAS broj | 37259-53-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Razlaže hijaluronatne lance na beta-D-GalNAc-(1->4)-beta-D-GlcA vezi, čime se polisaharid razlaže do 3-(4-dezoksi-beta-D-gluk-4-enuronozil)-N-acetil-D-glukozamina
Ovaj enzim takođe deluje na hondroitin.
Reference uredi
- ↑ Linker, A., Hoffman, P., Meyer, K., Sampson, P. and Korn, E.D. (1960). „The formation of unsaturated disacharides from mucopoly-saccharides and their cleavage to α-keto acid by bacterial enzymes”. J. Biol. Chem. 235: 3061-3061. PMID 13762462.
- ↑ Meyer, K. and Rapport, M.M. (1952). „Hyaluronidases”. Adv. Enzymol. Relat. Subj. Biochem. 13: 199-236. PMID 14943668.
- ↑ Moran, F., Nasuno, S. and Starr, M.P. (1968). „Extracellular and intracellular polygalacturonic acid trans-eliminases of Erwinia carotovora”. Arch. Biochem. Biophys. 123: 298-306. PMID 5642600.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.