Hidralazin
Hidralazin (apresolin) je direktno delujući relaksant glatkih mišića koji se koristi za tretman hipertenzije. On deluje kao vazodilatator prvenstveno u arterijama i arteriolama. Putem relaksacije vaskularnih glatkih mišića, vazodilatatori umanjuju perifernu otpornost, čime snižavaju krvni pritisak.[6] Međutim, ovaj lek ima samo kratkotrajno dejstvo na krvni pritisak.
| |||
| (IUPAC) ime | |||
|---|---|---|---|
| 1-hidrazinilftalazin | |||
| Klinički podaci | |||
| AHFS/Drugs.com | Monografija | ||
| MedlinePlus | a682246 | ||
| Identifikatori | |||
| CAS broj | 86-54-4 | ||
| ATC kod | C02DB02 | ||
| PubChem[1][2] | 3637 | ||
| DrugBank | DB01275 | ||
| ChemSpider[3] | 3511 | ||
| UNII | 26NAK24LS8 
| ||
| KEGG[4] | D08044
| ||
| ChEBI | CHEBI:5775
| ||
| ChEMBL[5] | CHEMBL276832
| ||
| Hemijski podaci | |||
| Formula | C8H8N4 | ||
| Mol. masa | 160,176 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakokinetički podaci | |||
| Bioraspoloživost | 26-55% | ||
| Metabolizam | Hepatički | ||
| Poluvreme eliminacije | 2-4 sata | ||
| Izlučivanje | Renalno | ||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
| Način primene | Oralno, intravenozno | ||
Hidralazin pripada hidrazinoftalazinskoj klasi lekova.[7]
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Harvey, Richard A., Pamela A. Harvey, and Mark J. Mycek. Lippincott's Illustrated Reviews: Pharmacology. 2nd ed. Philadelphia: Lipincott, Williams & Wilkins, 2000. 190.
- ↑ Bourreli, B.; Pinaud, M.; Passuti, N.; Gunst, J. P.; Drouet, J. C.; Remi, J. P. (1988). „Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion”. Canadian Journal of Anaesthesia 35 (3): 242–248. DOI:10.1007/BF03010617. PMID 3383316.
