Glutamin—fruktoza-6-fosfat transaminaza (izomerizacija)
Glutamin—fruktoza-6-fosfat transaminaza (izomerizacija) (EC 2.6.1.16, heksozafosfatna aminotransferaza, glukozamin-6-fosfatna izomeraza (formira glutamin), glutamin-fruktoza-6-fosfatna transaminaza (izomerizacija), D-fruktoza-6-fosfatna amidotransferaza, glukozaminfosfatna izomeraza, glukozamin 6-fosfatna sintaza, GlcN6P sintaza) je enzim sa sistematskim imenom L-glutamin:D-fruktoza-6-fosfat izomeraza (deaminacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
Glutamin—fruktoza-6-fosfat transaminaza (izomerizacija) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Glutamin—fruktoza-6-fosfat transaminaza 1, homodimer, Human | |||||||||
Identifikatori | |||||||||
EC broj | 2.6.1.16 | ||||||||
CAS broj | 9030-45-9 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
|
- L-glutamin + D-fruktoza 6-fosfat L-glutamat + D-glukozamin 6-fosfat
Mada je sveukupna reakcija tipična za transferaze, ona se odvija putem mehanizma koji obuhvata formiranje ketimina između fruktoza 6-fosfata i 6-amino grupa lizinskog ostatka aktivnog mesta.
Reference uredi
- ↑ Ghosh, S., Blumenthal, H.J., Davidson, E. and Roseman, S. (1960). „Glucosamine metabolism. V. Enzymatic synthesis of glucosamine 6-phosphate”. J. Biol. Chem. 235: 1265-1273. PMID 13827775.
- ↑ Gryder, R.M. and Pogell, B.M. (1960). „Further studies on glucosamine 6-phosphate synthesis by rat liver enzymes”. J. Biol. Chem. 235: 558-562. PMID 13829889.
- ↑ Leloir, L.F. and Cardini, C.E. (1953). „The biosynthesis of glucosamine”. Biochim. Biophys. Acta 12: 15-22. PMID 13115409.
- ↑ Teplyakov, A., Obmolova, G., Badet-Denisot, M.A. and Badet, B. (1999). „The mechanism of sugar phosphate isomerization by glucosamine 6-phosphate synthase”. Protein Sci. 8: 596-602. PMID 10091662.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.