Glukozamin-6-fosfatna deaminaza
Glukozamin-6-fosfatna deaminaza (EC 3.5.99.6, glukozaminfosfatna izomeraza, glukozamin-6-fosfatna izomeraza, fosfoglukozaminizomeraza, glukozamin fosfatna deaminaza, aminodezoksiglukozafosfatna izomeraza, fosfoglukozaminska izomeraza) je enzim sa sistematskim imenom 2-amino-2-dezoksi-D-glukoza-6-fosfat aminohidrolaza (ketolna izomerizacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glukozamin-6-fosfatna deaminaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 3.5.99.6 | ||||||||
| CAS broj | 2598253 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- D-glukozamin 6-fosfat + H2O D-fruktoza 6-fosfat + NH3
Izomerizacijom aldozna-ketoznog tipa se konvertuje -CH(-NH2)-CH=O grupa glukozamin 6-fosfata u -C(=NH)-CH2-OH, čime se formira 2-dezoksi-2-imino-D-arabino-heksitol.
Reference uredi
- ↑ Comb, D.G., Roseman, S. (1958). „Glucosamine metabolism. IV. Glucosamine-6-phosphate deaminase”. J. Biol. Chem. 232: 807-827. PMID 13549465.
- ↑ Pattabiraman, T.N., Bachhawat, B.K. (1961). „Purification of glucosamine 6-phosphate deaminase from human brain”. Biochim. Biophys. Acta 54: 273-283. PMID 14484386.
- ↑ Wolfe, J.B., Britton, B.B., Nakada, H.I. (1957). „Glucosamine degradation by Escherichia coli. III. Isolation and studies of "phosphoglucosaminisomerase"”. Arch. Biochem. Biophys. 66: 333-339. PMID 13403679.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.