Glicin/sarkozin/dimetilglicin N-metiltransferaza
Glicin/sarkozin/dimetilglicin N-metiltransferaza (EC 2.1.1.162, GSDMT, glicin sarkozin dimetilglicinska N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:glicin(ili sarkozin ili N,N-dimetilglicin) N-metiltransferaza (formira sarkozin(or N,N-dimetilglicin or betain)).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
Glicin/sarkozin/dimetilglicin N-metiltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.1.1.162 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 3 S-adenozil-L-metionin + glicin 3 S-adenozil-L-homocistein + betain (sveukupna reakcija)
- (1a)'S-adenozil-L-metionin + glicin S-adenozil-L-homocistein + sarkozin
- (1b)'S-adenozil-L-metionin + sarkozin S-adenozil-L-homocistein + N,N-dimetilglicin
- (1c) S-adenozil-L-metionin + N,N-dimetilglicin S-adenozil-L-homocistein + betain
Za razliku od EC 2.1.1.156 (glicin/sarkozin N-metiltransferaze), EC 2.1.1.157 (sarkozin/dimetilglicin N-metiltransferaze) i EC 2.1.1.161 (dimetilglicin N-metiltransferaze), ovaj enzim, iz halofilne metanoarcheje metanohalophilus portucalensis, može da metiluje glicin i sve njegove intermedijere.
Reference uredi
- ↑ Lai, M.C., Wang, C.C., Chuang, M.J., Wu, Y.C. and Lee, Y.C. (2006). „Effects of substrate and potassium on the betaine-synthesizing enzyme glycine sarcosine dimethylglycine N-methyltransferase from a halophilic methanoarchaeon Methanohalophilus portucalensis”. Res. Microbiol. 157: 948-955. PMID 17098399.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.