Geranil difosfat 2-C-metiltransferaza
Geranil difosfat 2-C-metiltransferaza (EC 2.1.1.255, SCO7701, GPP metiltransferaza, GPPMT, 2-metil-GPP sintaza, MGPPS, geranil pirofosfatna metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:geranil-difosfat 2-C-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Geranil difosfat 2-C-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.255 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + geranil difosfat S-adenozil-L-homocistein + (E)-2-metilgeranil difosfat
Ovaj enzim, zajedno sa [[EC 4.2.3.118], 2-metilizoborneol sintazom, formira 2-metilizoborneol. Ovo jedinjenje jakog mirisa ustajale zemlje proizvode zemljišni mikroorganizmi.
Reference uredi
- ↑ Wang, C.M. and Cane, D.E. (2008). „Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor”. J. Am. Chem. Soc. 130: 8908-8909. PMID 18563898.
- ↑ Ariyawutthiphan, O., Ose, T., Tsuda, M., Gao, Y., Yao, M., Minami, A., Oikawa, H. and Tanaka, I. (2011). „Crystallization and preliminary X-ray crystallographic study of a methyltransferase involved in 2-methylisoborneol biosynthesis in Streptomyces lasaliensis”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 67: 417-420. PMID 21393856.
- ↑ Komatsu, M., Tsuda, M., Omura, S., Oikawa, H. and Ikeda, H. (2008). „Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol”. Proc. Natl. Acad. Sci. USA 105: 7422-7427. PMID 18492804.
- ↑ Giglio, S., Chou, W.K., Ikeda, H., Cane, D.E. and Monis, P.T. (2011). „Biosynthesis of 2-methylisoborneol in cyanobacteria”. Environ. Sci. Technol. 45: 992-998. PMID 21174459.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.