Galamin

Galamin
(IUPAC) ime
	2,2’,2’’-[benzen-1,2,3-triiltris(oksi)]tris(N,N,N-trietiletanaminijum) trijodid
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	65-29-2
ATC kod	M03AC02
PubChem	6172
DrugBank	APRD00712
ChemSpider	5937
UNII	Q3254X40X2
KEGG	D02292
ChEBI	CHEBI:503442
ChEMBL	CHEMBL1200993
Hemijski podaci
Formula	C24H45N3O3 (galamin)
Mol. masa	891,529 g/mol (galamin trietjodid); 423,633 g/mol; (galamin)
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C24H45N3O3/c1-7-25(8-2)16-19-28-22-14-13-15-23(29-20-17-26(9-3)10-4)24(22)30-21-18-27(11-5)12-6/h13-15H,7-12,16-21H2,1-6H3 ; Key: ICLWTJIMXVISSR-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Galamin trietjodid (Flaksedil) je nedepolarizirajući mišićni relaksant.^[6] On deluje na aktivno mesto holinergčkog receptora u mišićima čime kompetitivno blokira prenos acetilholinskog signala.^[7] Galamin trietjodid ima parasimpatolitičko dejstvo na srčani živac lutalac koji uzrokuje tahikardiju i povremeno hipertenziju. Veoma visoke doze uzrokuju otpuštanje histamina.

Galamin trietjodid se koristi za stabilizaciju mišićnih kontrakcija tokom hirurških postupaka.

Ovaj lek je razvila kompanija Daniel Bovet 1947.^[8]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ „Webster's Online Dictionary - Flaxedil”. Pristupljeno 15. 12. 2008.
↑ „RxMed: Pharmaceutical Information - FLAXEDIL”. Pristupljeno 15. 12. 2008.
↑ Raghavendra T (July 2002). „Neuromuscular blocking drugs: discovery and development”. J R Soc Med 95 (7): 363–7. DOI:10.1258/jrsm.95.7.363. PMC 1279945. PMID 12091515.

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] „Webster's Online Dictionary - Flaxedil”. Pristupljeno 15. 12. 2008.

[7] „RxMed: Pharmaceutical Information - FLAXEDIL”. Pristupljeno 15. 12. 2008.

[pmid12091515-8] Raghavendra T (July 2002). „Neuromuscular blocking drugs: discovery and development”. J R Soc Med 95 (7): 363–7. DOI:10.1258/jrsm.95.7.363. PMC 1279945. PMID 12091515.

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