Gadopentetat dimeglumin

Gadopentetat dimeglumin
	gadolinijum(3+) jon bis((2R,3R,4R,5S)-6-(metilamino)heksan-1,2,3,4,5-pentol) 2-[bis({2-[(karboksilatometil)(karboksimetil)amino]etil})amino]acetat
Drugi nazivi	Gadopentetic Acid Dimeglumine Salt, Magnevist
Identifikacija
CAS registarski broj	86050-77-3
PubChem	55466
ChemSpider	50087
DrugBank	DB00789
ChEBI	31797
ATC code	V08CA03,, V08CA01
Jmol-3D slike	Slika 1
SMILES
	[Gd+3].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)CN(CCN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O)CC([O-])=O
InChI
	InChI=1S/C14H23N3O10.2C7H17NO5.Gd/c18-10(19)5-15(1-3-16(6-11(20)21)7-12(22)23)2-4-17(8-13(24)25)9-14(26)27;21-8-2-4(10)6(12)7(13)5(11)3-9;/h1-9H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,26,27);24-13H,2-3H2,1H3;/q;;;+3/p-3/t;2*4-,5+,6+,7+;/m.00./s1 ; Kod: LGMLJQFQKXPRGA-VPVMAENOSA-K
Svojstva
Molekulska formula	C28H54N5O20
Molarna masa	780.75 g mol−1
Farmakologija
Načini upotrebe	Intravenozno
Vreme polu-uklanjanja iz organizma	12 minuta
Ekskrecija	Gadopentetat se ekskluzivno eliminiše putem urina
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Gadopentetat dimeglumin je kompleks gadolinijuma sa helirajućim agensom, dietilentriamin penta-acetatnom kiselinom (DTPA), koji se koristi za pojačavanje slike kranijalnih i kičmenih MRI snimaka.^[4]^[5]^[6]

ReferenceUredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Martindale, The Extra Pharmacopoeia, 30th ed, p706
↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
↑ Nucleic Acids Res (2008). DrugBank: a knowledgebase for drugs, drug actions and drug targets. 36. pp. D901-6. PMID 18048412.

Spoljašnje vezeUredi

Portal Hemija

Gadopentetic acid

Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Martindale, The Extra Pharmacopoeia, 30th ed, p706

[5] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.

[6] Nucleic Acids Res (2008). DrugBank: a knowledgebase for drugs, drug actions and drug targets. 36. pp. D901-6. PMID 18048412.

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