Metabotropni glutamatni receptor 8

Metabotropni glutamatni receptor 8
Identifikatori
Simboli	GRM8; GLUR8; GPRC1H; MGLUR8; mGlu8
Vanjski ID	OMIM: 601116 MGI: 1351345 HomoloGene: 654 IUPHAR: mGlu8 GeneCards: GRM8 Gene
Ontologija gena
Molekularna funkcija	• aktivnost grupe III metabotropnih glutamatnih receptora; • aktivnost prenosa signala; • receptorska aktivnost; • aktivnost G protein spregnutog receptora; • aktivnost glutamatnog receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom; • presinaptička membrana; • neuronska projekcija; • neuronsko ćelijsko telo;
Biološki proces	• signalni put G protein spregnutog receptora; • negativna regulacija aktivnosti adenilat ciklaze; • inhibicicija aktivnosti adenilat ciklaze signalnim putem G protein spregnutog glutamatog receptora; • vizuelna percepcija; • senzorna percepcija mirisa;
Ortolozi

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Metabotropni glutamatni receptor 8 je protein koji je kod ljudi kodiran GRM8 genom.^[1]^[2]

Funkcija uredi

Aminokiselina L-glutamat je glavni ekscitatorni neurotransmiter u centralnom nervnom sistemu koji aktivira jonotropne i metabotropne glutamatne receptore. Glutamatergična neurotransmisija učestvuje u većini aspekata normalnih moždanih funkcija. Ona može da bude poremećena u mnogim neuropatološkim oboljenjima. Metabotropni glutamatni receptori su familija G protein spregnutih receptora, koja se deli u tri grupe na osnovu homologije sekvence, mehanizma prenosa signala, i farmakoloških svojstava. Grupa I obuhvata GRM1 i GRM5. Ovi receptori aktiviraju fosfolipazu C. Grupa II obuhvata GRM2 i GRM3, dok su u grupi III GRM4, GRM6, GRM7, i GRM8. Receptori grupe II i III su vezani za inhibiciju kaskade cikličnog AMP-a ali se razlikuju u njihovim selektivnostima za agoniste. Alternativne splajsne varijante GRM8 su poznate, ali njihova svojstava nisu potpuno određena.^[2]

Ligandi uredi

(S)-3,4-DCPG: agonist^[3]

Reference uredi

↑ Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC (Mar 1997). „Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q”. Genomics 31 (2): 230–3. DOI:10.1006/geno.1996.0036. PMID 8824806.
↑ ^2,0 ^2,1 „Entrez Gene: GRM8 glutamate receptor, metabotropic 8”.
↑ Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE (2001). „(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord”. Neuropharmacology 40 (3): 311–8. DOI:10.1016/S0028-3908(00)00169-6. PMID 11166323.

Literatura uredi

Scherer SW, Soder S, Duvoisin RM, et al. (1997). „The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1”. Genomics 44 (2): 232–6. DOI:10.1006/geno.1997.4842. PMID 9299241.
Wu S, Wright RA, Rockey PK, et al. (1998). „Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells”. Brain Res. Mol. Brain Res. 53 (1–2): 88–97. DOI:10.1016/S0169-328X(97)00277-5. PMID 9473604.
Malherbe P, Kratzeisen C, Lundstrom K, et al. (1999). „Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8”. Brain Res. Mol. Brain Res. 67 (2): 201–10. DOI:10.1016/S0169-328X(99)00050-9. PMID 10216218.
Thomas NK, Wright RA, Howson PA, et al. (2001). „(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord”. Neuropharmacology 40 (3): 311–8. DOI:10.1016/S0028-3908(00)00169-6. PMID 11166323.
Enz R (2002). „The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7”. FEBS Lett. 514 (2–3): 184–8. DOI:10.1016/S0014-5793(02)02361-X. PMID 11943148.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tang Z, El Far O, Betz H, Scheschonka A (2006). „Pias1 interaction and sumoylation of metabotropic glutamate receptor 8”. J. Biol. Chem. 280 (46): 38153–9. DOI:10.1074/jbc.M508168200. PMID 16144832.
Kobayashi Y, Akiyoshi J, Kanehisa M, et al. (2007). „Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder”. Psychiatr. Genet. 17 (1): 9. DOI:10.1097/YPG.0b013e32801118bc. PMID 17167337.

Vidi još uredi

Metabotropni glutamatni receptor

Spoljašnje veze uredi

„Metabotropic Glutamate Receptors: mGlu₈”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.

[pmid8824806-1] Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC (Mar 1997). „Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q”. Genomics 31 (2): 230–3. DOI:10.1006/geno.1996.0036. PMID 8824806.

[entrez-2] 2,0 ^2,1 „Entrez Gene: GRM8 glutamate receptor, metabotropic 8”.

[pmid11166323-3] Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE (2001). „(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord”. Neuropharmacology 40 (3): 311–8. DOI:10.1016/S0028-3908(00)00169-6. PMID 11166323.

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