GPR6
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GPR6, G protein-spregnuti receptor 6, je protein koji je kod čoveka kodiran GPR6 genom.[1][2]
| G protein-spregnuti receptor 6 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | GPR6; | ||||||||||
| Vanjski ID | OMIM: 600553 MGI: 2155249 HomoloGene: 38026 IUPHAR: GPR6 GeneCards: GPR6 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2830 | 140741 | |||||||||
| Ensembl | ENSG00000146360 | ENSMUSG00000046922 | |||||||||
| UniProt | P46095 | Q2M2N8 | |||||||||
| RefSeq (mRNA) | NM_005284 | NM_199058 | |||||||||
| RefSeq (protein) | NP_005275 | NP_951013 | |||||||||
| Lokacija (UCSC) | Chr 6: 110.41 - 110.41 Mb | Chr 10: 40.76 - 40.76 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Funkcija uredi
GPR6 je član familije GPCR transmembranskih receptora. Postoje tvrdnje da je GPR6 konstitutivno aktivan, i da se dodatno aktivira sfingozin-1-fosfatom.[3]
GPR6 povišava nivoe cikličnog AMP i promoviše rast neurita.[4]
Vidi još uredi
Literatura uredi
- ↑ „Entrez Gene: GPR6 G protein-coupled receptor 6”.
- ↑ Song ZH, Modi W, Bonner TI (July 1995). „Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors”. Genomics 28 (2): 347–9. DOI:10.1006/geno.1995.1154. PMID 8530049.
- ↑ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). „Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors”. Cellular Signalling 14 (11): 941–53. DOI:10.1016/S0898-6568(02)00041-4. PMID 12220620.
- ↑ Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). „Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth”. The Journal of Biological Chemistry 282 (14): 10506–15. DOI:10.1074/jbc.M700911200. PMID 17284443.
Dodatna literatura uredi
- Heiber M, Docherty JM, Shah G, et al. (1995). „Isolation of three novel human genes encoding G protein-coupled receptors.”. DNA Cell Biol. 14 (1): 25–35. DOI:10.1089/dna.1995.14.25. PMID 7832990.
- Song ZH, Modi W, Bonner TI (1996). „Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.”. Genomics 28 (2): 347–9. DOI:10.1006/geno.1995.1154. PMID 8530049.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Uhlenbrock K, Huber J, Ardati A, et al. (2003). „Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.”. Cell. Physiol. Biochem. 13 (2): 75–84. DOI:10.1159/000070251. PMID 12649592.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). „The DNA sequence and analysis of human chromosome 6.”. Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.