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GPR18, N-arahidonil glicinski receptor, je protein koji je kod čoveka kodiran GPR18 genom.[1][2] Zajedno sa drugim „orfanskim“ receptorima GPR55 i GPR119, za GPR18 je utvrđeno da je receptor za endogene lipidne neurotransmitere, nekoliko od kojih se takođe vezuju za kanabinoidne receptore.[3][4][5] Nedavna istraživanja daju snažnu podršku hipotezi da GPR18 predstavlja abnormalni kanabidiolni receptor, i sugerišu da N-arahidonoil glicin, endogeni lipidni metabolit anandamida, inicira usmerenu mikroglijalnu migraciju u CNS-u putem GPR18 aktivacije.[6]

G protein-spregnuti receptor 18
Identifikatori
SimboliGPR18;
Vanjski IDOMIM602042 MGI107859 HomoloGene18814 IUPHAR: GPR18 GeneCards: GPR18 Gene
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez2841110168
EnsemblENSG00000125245ENSMUSG00000050350
UniProtQ14330n/a
RefSeq (mRNA)NM_005292NM_182806
RefSeq (protein)NP_005283NP_877958
Lokacija (UCSC)Chr 13:
98.7 - 98.71 Mb
Chr 14:
121.05 - 121.05 Mb
PubMed pretraga[1][2]

Ligandi uredi

Ligandi za koje je utvrđeno da vezuju GPR18 su:[6]

Reference uredi

  1. Gantz I, Muraoka A, Yang YK, Samuelson LC, Zimmerman EM, Cook H, Yamada T (Sep 1997). „Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis”. Genomics 42 (3): 462–6. DOI:10.1006/geno.1997.4752. PMID 9205118. 
  2. „Entrez Gene: GPR18 G protein-coupled receptor 18”. 
  3. Kohno M, Hasegawa H, Inoue A, Muraoka M, Miyazaki T, Oka K, Yasukawa M (September 2006). „Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18”. Biochemical and Biophysical Research Communications 347 (3): 827–32. DOI:10.1016/j.bbrc.2006.06.175. PMID 16844083. 
  4. Burstein S (December 2008). „The elmiric acids: biologically active anandamide analogs”. Neuropharmacology 55 (8): 1259–64. DOI:10.1016/j.neuropharm.2007.11.011. PMC 2621443. PMID 18187165. 
  5. Bradshaw HB, Lee SH, McHugh D (September 2009). „Orphan endogenous lipids and orphan GPCRs: a good match”. Prostaglandins & Other Lipid Mediators 89 (3-4): 131–4. DOI:10.1016/j.prostaglandins.2009.04.006. PMC 2740803. PMID 19379823. 
  6. 6,0 6,1 McHugh D, Hu SS, Rimmerman N, Juknat A, Vogil Z, Walker JM, Bradshaw HB (March 2010). „N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor”. BMC Neuroscience 11 (1): 44. DOI:10.1186/1471-2202-11-44. PMC 2865488. PMID 20346144. 

Literatura uredi