GPR120
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GPR120, G protein-spregnuti receptor 120, je protein koji je kod čoveka kodiran GPR120 genom.[1][2] i Za GPR120 je bilo pokazano da posreduje antiinflamatorne i insulin-senzibilizujuće efekte omega 3 masnih kiselina.[3]
| G protein-spregnuti receptor 120 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | GPR120; GPR129; GT01; MGC119984; PGR4 | ||||||||||
| Vanjski ID | OMIM: 609044 MGI: 2147577 HomoloGene: 18769 IUPHAR: GPR120 GeneCards: GPR120 Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 338557 | 107221 | |||||||||
| Ensembl | ENSG00000186188 | ENSMUSG00000054200 | |||||||||
| UniProt | Q5NUL3 | Q3V2S5 | |||||||||
| RefSeq (mRNA) | NM_181745 | NM_181748 | |||||||||
| RefSeq (protein) | NP_859529 | NP_861413 | |||||||||
| Lokacija (UCSC) | Chr 10: 95.32 - 95.34 Mb | Chr 19: 38.16 - 38.18 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Referebce uredi
- ↑ Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB (Nov 2003). „Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives”. FEBS Lett 554 (3): 381–8. DOI:10.1016/S0014-5793(03)01196-7. PMID 14623098.
- ↑ „Entrez Gene: GPR120 G protein-coupled receptor 120”.
- ↑ Oh DY, Talukdar S, Bae EJ, et al. (September 2010). „GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects”. Cell 142 (5): 687–98. DOI:10.1016/j.cell.2010.07.041. PMID 20813258. Pristupljeno 2011-04-09.
Literatura uredi
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). „The G protein-coupled receptor repertoires of human and mouse.”. Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. DOI:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). „The DNA sequence and comparative analysis of human chromosome 10.”. Nature 429 (6990): 375–81. DOI:10.1038/nature02462. PMID 15164054.
- Hirasawa A, Tsumaya K, Awaji T, et al. (2005). „Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.”. Nat. Med. 11 (1): 90–4. DOI:10.1038/nm1168. PMID 15619630.
- Oh JH, Yang JO, Hahn Y, et al. (2006). „Transcriptome analysis of human gastric cancer.”. Mamm. Genome 16 (12): 942–54. DOI:10.1007/s00335-005-0075-2. PMID 16341674.