Furazolidon

Furazolidon
(IUPAC) ime
	3[(5-nitro-2-furil)metilen]amino1,3-oksazolidin-2-on
Klinički podaci
AHFS/Drugs.com	Mikromedeks, detaljne potrošačke informacije
Identifikatori
CAS broj	67-45-8
ATC kod	G01AX06 QJ01XE90
PubChem	3435
DrugBank	DB00614
ChemSpider	3317
UNII	5J9CPU3RE0
KEGG	C07999
ChEMBL	CHEMBL1103
Hemijski podaci
Formula	C8H7N3O5
Mol. masa	225,16
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2 ; Key: PLHJDBGFXBMTGZ-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	Oralno, lokalno

Furazolidon je nitrofuranski antibiotik. Ovaj lek proizvodi i prodaje preduzeće Roberts Laboratories pod imenom Furokson i GlaxoSmithKline kao Dependal-M.

Upotreba

Furazolidon se koristi u medicini i veterini. Oni ima širok spektara dejstava protiv

Gram positivne bakterije
Gram negativne bakterije
- Escherichia coli
- Salmonella dublin
- Salmonella typhimurium
Protozoa
- Giardia lamblia
- Eimeria vrste
- Histomonas meleagridis

Medicinska upotreba

Ovaj lek se koristi za tretiranje dijareja i enteritisa uzrokovanog bakterijskim ili protozoalnim infekcijama. On je korišten za tretman putničke dijareje, kolere i bacteremic salmonellosis. Primena ovog leka u lečenju infekcija Helicobacter pylori je takođe predložena.^[6]

Furazolidone je korišten za tretman giardija (uzkovananih vrstom Giardia lamblia), mada on nije primarni tretman.^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Machado RS, Silva MR, Viriato A (2008). „Furazolidone, tetracycline and omeprazole: a low-cost alternative for Helicobacter pylori eradication in children”. Jornal de pediatria 84 (2): 160–5. DOI:10.2223/JPED.1772. PMID 18372934.
↑ Petri WA (February 2005). „Treatment of Giardiasis”. Curr Treat Options Gastroenterol 8 (1): 13–17. DOI:10.1007/s11938-005-0047-3. PMID 15625030.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Šablon:Antibiotici inhibitori nukleinskih kiselina

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid18372934-6] Machado RS, Silva MR, Viriato A (2008). „Furazolidone, tetracycline and omeprazole: a low-cost alternative for Helicobacter pylori eradication in children”. Jornal de pediatria 84 (2): 160–5. DOI:10.2223/JPED.1772. PMID 18372934.

[pmid15625030-7] Petri WA (February 2005). „Treatment of Giardiasis”. Curr Treat Options Gastroenterol 8 (1): 13–17. DOI:10.1007/s11938-005-0047-3. PMID 15625030.

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