Fosfatidiletanolamin N-metiltransferaza

Fosfatidiletanolamin N-metiltransferaza
Identifikatori
EC broj	2.1.1.17
CAS broj	37256-91-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Fosfatidiletanolamin N-metiltransferaza (EC 2.1.1.17, PEMT, LMTaza, lipidno metilna transferaza, fosfatidiletanolaminska metiltransferaza, fosfatidiletanolamin-N-metilaza, fosfatidiletanolamin-S-adenozilmetioninska metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:fosfatidiletanolamin N-metiltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + fosfatidiletanolamin

\rightleftharpoons

S-adenozil-L-homocistein + fosfatidil-N-metiletanolamin

Reference uredi

↑ Hirata, F., Viveros, O.H., Diliberto, E.J., Jr. and Axelrod, J. (1978). „Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine”. Proc. Natl. Acad. Sci. USA 75: 1718-1721. PMID 25437.
↑ Morgan, T.E. (1969). „Isolation and characterization of lipid N-methyltransferase from dog lung”. Biochim. Biophys. Acta 178: 21-34. PMID 5773456.
↑ Schneider, W.J. and Vance, D.E. (1979). „Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities”. J. Biol. Chem. 254: 3886-3891. PMID 438165.

Literatura uredi

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze uredi

MeSH Phosphatidylethanolamine+N-methyltransferase

[1] Hirata, F., Viveros, O.H., Diliberto, E.J., Jr. and Axelrod, J. (1978). „Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine”. Proc. Natl. Acad. Sci. USA 75: 1718-1721. PMID 25437.

[2] Morgan, T.E. (1969). „Isolation and characterization of lipid N-methyltransferase from dog lung”. Biochim. Biophys. Acta 178: 21-34. PMID 5773456.

[3] Schneider, W.J. and Vance, D.E. (1979). „Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities”. J. Biol. Chem. 254: 3886-3891. PMID 438165.

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