Ferohelataza
Ferohelataza (EC 4.99.1.1, fero-protoporfirin helataza, gvožđe helataza, hem sintetaza, hem sintaza, protoheme fero-lijaza) je enzim sa sistematskim imenom protohem fero-lijaza (formira protoporfirin).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Ferohelataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 4.99.1.1 | ||||||||
| CAS broj | 9012-93-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- protohem + 2 H+ protoporfirin + Fe2+
Reference uredi
- ↑ Bloomer, J.R., Hill, H.D., Morton, K.O., Anderson-Burnham, L.A. and Straka, J.G. (1987). „The enzyme defect in bovine protoporphyria. Studies with purified ferrochelatase”. J. Biol. Chem. 262: 667-671. PMID 3805002.
- ↑ Porra, R.J. and Jones, O.T. (1963). „Studies on ferrochelatase. 1. Assay and properties of ferrochelatase from a pig-liver mitochondrial extract”. Biochem. J. 87: 181-185. PMID 13972328.
- ↑ Porra, R.J. and Jones, O.T. (1963). „Studies on ferrochelatase. 2. An investigation of the role of ferrochelatase in the biosynthesis of various haem prosthetic groups”. Biochem. J. 87: 186-192. PMID 13972329.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.