Fenoldopam

Fenoldopam
(IUPAC) ime
	(RS)-6-hloro-1-(4-hidroksifenil)-2,3,4,5-tetrahidro-1H-3-benzazepin-7,8-diol
Klinički podaci
Robne marke	Korlopam
AHFS/Drugs.com	Monografija
Identifikatori
CAS broj	67227-57-0
ATC kod	C01CA19
PubChem	3341
DrugBank	APRD00969
ChemSpider	3224
UNII	HA3R0MY016
KEGG	D07946
ChEBI	CHEBI:5002
ChEMBL	CHEMBL588
Hemijski podaci
Formula	C16H16ClNO3
Mol. masa	305,76 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2 ; Key: TVURRHSHRRELCG-UHFFFAOYSA-N
Farmakokinetički podaci
Metabolizam	Hepatic (CYP ne učestvuje)
Poluvreme eliminacije	5 minuta
Izlučivanje	Renalno (90%) i fekalno (10%)
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	IV

Fenoldopam (Korlopam) je lek i sintetički derivat benzazepina koji deluje kao periferni selektivni parcijalni agonist/antagonist D₁ receptora. On se koristi kao antihipertenziv.^[6] FDA je odobrila fenoldopam 1997.^[7]

Indikacije uredi

Fenoldopam se postoperativno koristi kao antihipertenzivni agens, kao i IV putem za lečenje hipertenzivna kriza.^[8] Fenoldopam je jedini intravenozni agens koji poboljšava renalnu perfuziju, te može da bude koristan kod pacijenata sa pratećom insuficijencijom bubrega.^[9]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Oliver WC, Nuttall GA, Cherry KJ, Decker PA, Bower T, Ereth MH (October 2006). „A comparison of fenoldopam with dopamine and sodium nitroprusside in patients undergoing cross-clamping of the abdominal aorta”. Anesth. Analg. 103 (4): 833–40. DOI:10.1213/01.ane.0000237273.79553.9e. PMID 17000789.
↑ accessed November 14, 2011
↑ Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. str. 9. ISBN 1-59541-101-1.
↑ USMLE WORLD 2009 Step1 QBanks, Pharmacology, Pharma50q, Q NO 18

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid17000789-6] Oliver WC, Nuttall GA, Cherry KJ, Decker PA, Bower T, Ereth MH (October 2006). „A comparison of fenoldopam with dopamine and sodium nitroprusside in patients undergoing cross-clamping of the abdominal aorta”. Anesth. Analg. 103 (4): 833–40. DOI:10.1213/01.ane.0000237273.79553.9e. PMID 17000789.

[7] ssed November 14, 2011

[pharmnemonics-8] Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. str. 9. ISBN 1-59541-101-1.

[9] USMLE WORLD 2009 Step1 QBanks, Pharmacology, Pharma50q, Q NO 18

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