Fenilpiperazin

Fenilpiperazin
	1-phenylpiperazine
Identifikacija
CAS registarski broj	92-54-6
PubChem	7096
ChemSpider	6829
ChEMBL	CHEMBL9434
Jmol-3D slike	Slika 1
SMILES
	c1cc(ccc1)N2CCNCC2
InChI
	InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2 ; Kod: YZTJYBJCZXZGCT-UHFFFAOYSA-N InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2 InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2; Kod: YZTJYBJCZXZGCT-UHFFFAOYSA-N
Svojstva
Molekulska formula	C10H14N2
Molarna masa	162.23 g/mol
Agregatno stanje	čista bezbojna do žute tečnosti
Gustina	1.028g/cm3
Tačka topljenja	18.8 °C
Tačka ključanja	287.2 °C @ 760mmHg
Rastvorljivost u vodi	nerastvoran
Opasnost
Tačka paljenja	138.3 °C
	; ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

1-Fenilpiperazin je jednostavno hemijsko jedinjenje koje sadrži fenilna grupa:fenilnu grupu vezanu za piperazinski prsten. Sufiks '-piprazol' se ponekad koristi u imenima lekova da se naznači da pripadaju ovoj klasi.^[5]^[6]

Brojni fenilpiperazinski derivati su lekovi. Neki od njih su:

Lekovi
- Antrafenin - Antiinflamatorni lek
- Aripiprazol - Antipsihotik
- Ciprofloksacin - Antibiotic
- Dapiprazol - Alfa blokator
- Dropropizin - Antitusiv
- Etoperidon - Antidepresiv
- Itrakonazol - Antifungal
- Ketokonazol - Antifungal
- Levodropropizin - Antitusiv
- Mepiprazol - Anksiolitik
- Naftopidil - Antihipertenziv
- Nefazodon - Antidepresiv
- Niaprazin - Hipnotik
- Oksipertin - Antipsihotik
- Posakonazol - Antifungal
- Trazodon - Antidepresiv
- Urapidil - Antihipertenziv
- Vesnarinon - Kardiotonik
Istraživačke hemikalije
- Akaprazin - Anksiolytik
- Batoprazin - Serenik
- Bifeprunoks - Antipsihotik
- BRL-15,572 - Serotonergik
- CSP-2503 - Anksiolitik
- DMPP - Nikotinik
- EGIS-12,233 - Serotonergik
- Elopiprazol - Antipsihotik
- Eltoprazin - Serenik
- Enpiprazol - Anksiolitik
- Ensakulin - Nootropik
- Flibanserin - Afrodizijak
- Fluprazin - Serenik
- Flesinoksan - Antidepresiv
- Lorpiprazol - Anksiolitik
- Naftilpiperazin - Serotonergik
- Pardoprunoks - Antiparkinsonijan
- PRX-00023 - Antidepresiv
- S-14,506 - Serotonergik
- S-14,671 - Serotonergik
- S-15,535 - Serotonergik
- SB-258,585 - Serotonergik
- SB-271,046 - Serotonergik
- SB-357,134 - Serotonergik
- SB-399,885 - Serotonergik
- Sonepiprazol - Dopaminergik
- Tolpiprazol - Anksiolitik
- Vilazodon - Antidepresiv
- WAY-100,135 - Serotonergik
- WAY-100,635 - Serotonergik
Lekovi u razvoju
- DCPP - Serotonergik
- mCPP - Serotonergik
- MeOPP - Serotonergik
- pCPP - Serotonergic
- pFPP - Serotonergic
- TFMPP - Serotonergik

Vidi još uredi

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ World Health Organization (WHO) (2006). „The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances” (PDF). Pristupljeno April 2010.
↑ Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 izd.). New York: McGraw-Hill. ISBN 0-07-142280-3.

Literatura uredi

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[The_use_of_stems_in_the_selection_of_International_Nonproprietary_Names_(INN)_for_pharmaceutical_substances-5] World Health Organization (WHO) (2006). „The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances” (PDF). Pristupljeno April 2010.

[6] Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 izd.). New York: McGraw-Hill. ISBN 0-07-142280-3.

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