Fenilaceton monooksigenaza
Fenilaceton monooksigenaza (EC 1.14.13.92, PAMO) je enzim sa sistematskim imenom fenilaceton,NADPH:kiseonik oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fenilaceton monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.92 | ||||||||
| CAS broj | 1005768-90-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- fenilaceton + NADPH + H+ + O2 benzil acetat + NADP+ + H2O
Ovaj nezim je flavoprotein (FAD). NADH ne može da zameni NADPH kao koenzim.
Reference uredi
- ↑ Malito, E., Alfieri, A., Fraaije, M.W. and Mattevi, A. (2004). „Crystal structure of a Baeyer-Villiger monooxygenase”. Proc. Natl. Acad. Sci. USA 101: 13157-13162. PMID 15328411.
- ↑ Fraaije, M.W., Wu, J., Heuts, D.P., van Hellemond, E.W., Spelberg, J.H. and Janssen, D.B. (2005). „Discovery of a thermostable Baeyer-Villiger monooxygenase by genome mining”. Appl. Microbiol. Biotechnol. 66: 393-400. PMID 15599520.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.