FZD7

Uvojiti receptor 7
Identifikatori
Simboli	FZD7; FzE3
Vanjski ID	OMIM: 603410 MGI: 108570 HomoloGene: 20751 IUPHAR: FZD7 GeneCards: FZD7 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora; • receptorsko vezivanje; • proteinsko vezivanje; • Wnt proteinsko vezivanje; • vezivanje PDZ domena;
Celularna komponenta	• citoplazma; • ćelijska površina; • integralno sa membranom; • sinaptosom; • membrana neuronske projekcije;
Biološki proces	• pozitivna regulacija proteinske fosforilacije; • razvoj vaskulature; • morfogeneza odlivnog trakta; • signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom;
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Uvojiti-7 je protein koji je kod ljudi kodiran FZD7 genom.^[1]^[2]^[3]

Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD7 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. Izražavanje FZD7 gena može da umanji APC funkciju i pojača beta-katenin-posredovane signale u slabo diferenciranom ljudskim karcinomima jednjaka.^[3]

Interakcije uredi

FZD7 formira interakcije sa DLG4.^[4]

Reference uredi

↑ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals”. Proc Natl Acad Sci U S A 95 (17): 10164–9. DOI:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
↑ Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). „Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7”. Biochem Biophys Res Commun 252 (1): 117–22. DOI:10.1006/bbrc.1998.9607. PMID 9813155.
↑ ^3,0 ^3,1 „Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)”.
↑ Hering, Heike; Sheng Morgan (June 2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”. FEBS Lett. (Netherlands) 521 (1–3): 185–9. DOI:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714.

Literatura uredi

Finch PW, He X, Kelley MJ, et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. DOI:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
Hering H, Sheng M (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”. FEBS Lett. 521 (1–3): 185–9. DOI:10.1016/S0014-5793(02)02831-4. PMID 12067714.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yao R, Natsume Y, Noda T (2005). „MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap”. Oncogene 23 (36): 6023–30. DOI:10.1038/sj.onc.1207817. PMID 15195140.
Omoto S, Hayashi T, Kitahara K, et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Vincan E, Darcy PK, Smyth MJ, et al. (2005). „Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth”. Differentiation 73 (4): 142–53. DOI:10.1111/j.1432-0436.2005.00015.x. PMID 15901282.
Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
Lim J, Hao T, Shaw C, et al. (2006). „A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration”. Cell 125 (4): 801–14. DOI:10.1016/j.cell.2006.03.032. PMID 16713569.
Vincan E, Darcy PK, Farrelly CA, et al. (2007). „Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids”. Oncogene 26 (16): 2340–52. DOI:10.1038/sj.onc.1210026. PMID 17016432.
Struewing IT, Barnett CD, Zhang W, et al. (2007). „Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1”. Exp. Cell Res. 313 (16): 3526–41. DOI:10.1016/j.yexcr.2007.07.012. PMID 17716656.

Vidi još uredi

Uvojiti receptori

Spoljašnje veze uredi

„Frizzled Receptors: FZD₇”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.

[pmid9707618-1] Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals”. Proc Natl Acad Sci U S A 95 (17): 10164–9. DOI:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.

[pmid9813155-2] Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). „Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7”. Biochem Biophys Res Commun 252 (1): 117–22. DOI:10.1006/bbrc.1998.9607. PMID 9813155.

[entrez-3] 3,0 ^3,1 „Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)”.

[pmid12067714-4] Hering, Heike; Sheng Morgan (June 2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”. FEBS Lett. (Netherlands) 521 (1–3): 185–9. DOI:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714.

[1]

[2]

[3]

[4]