Enkefalin

	3D struktura Met-enkedalina, alfa-ugljenici su pokazani kao sfere i obeležene oznakom ostatka.
Identifikatori
Simbol	PENK
Entrez	5179
HUGO	8831
OMIM	131330
RefSeq	NM_006211
UniProt	P01210
Drugi podaci
Lokus	Hromozom 8 q23-q24

Enkefalin je pentapeptid koji učestvuje u regulaciji nocicepcije u telu. Enkefalini su endogeni ligandi opioidnih receptora. Otkriveni su 1975. Dve forme enkefalina s poznate, jedna sadrži leucin (leu), i druga metionin (met). Oba proteina su proizvod proenkefalinskog gena.^[2]

Met-enkefalin je Tyr-Gly-Gly-Phe-Met.
Leu-enkefalin| je Tyr-Gly-Gly-Phe-Leu.

Endogeni opioidni peptidiUredi

Postoje tri dobro karakterisane familije opioidnih peptida koje proizvodi telo: enkefalini, endorfini, i dinorfini. Peptidna sekvenca met-enkefalin je kodirana sa oba enkefalinskim i endorfinskim genom (takođe poznatim kao POMC gen); leu-enkefalinska peptidna sekvenca je kodirana sa enkefalinskim i dinorfinskim genom.^[3]

LiteraturaUredi

↑ PDB 1plx; Marcotte I, Separovic F, Auger M, Gagné SM (March 2004). „A multidimensional 1H NMR investigation of the conformation of methionine-enkephalin in fast-tumbling bicelles”. Biophys. J. 86 (3): 1587–600. DOI:10.1016/S0006-3495(04)74226-5. PMC 1303993. PMID 14990485. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1303993/.
↑ Noda M, Teranishi Y, Takahashi H, Toyosato M, Notake M, Nakanishi S, Numa S (June 1982). „Isolation and structural organization of the human preproenkephalin gene”. Nature 297 (5865): 431–4. PMID 6281660.
↑ R.S. Rapaka and R. L. Hawks (editors). „Opioid peptides: Molecular pharmacology, biosynthesis and analysis in a National Institute on Drug Abuse Research Monograph (#70), 1986.”. Arhivirano iz originala 2009-08-26. https://web.archive.org/web/20090826150330/http://drugabuse.gov/pdf/monographs/70.pdf.

Spoljašnje vezeUredi

MeSH Enkephalins

[pmid14990485-1] PDB 1plx; Marcotte I, Separovic F, Auger M, Gagné SM (March 2004). „A multidimensional 1H NMR investigation of the conformation of methionine-enkephalin in fast-tumbling bicelles”. Biophys. J. 86 (3): 1587–600. DOI:10.1016/S0006-3495(04)74226-5. PMC 1303993. PMID 14990485. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1303993/.

[pmid6281660-2] Noda M, Teranishi Y, Takahashi H, Toyosato M, Notake M, Nakanishi S, Numa S (June 1982). „Isolation and structural organization of the human preproenkephalin gene”. Nature 297 (5865): 431–4. PMID 6281660.

[3] R.S. Rapaka and R. L. Hawks (editors). „Opioid peptides: Molecular pharmacology, biosynthesis and analysis in a National Institute on Drug Abuse Research Monograph (#70), 1986.”. Arhivirano iz originala 2009-08-26. https://web.archive.org/web/20090826150330/http://drugabuse.gov/pdf/monographs/70.pdf.

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