Elongacioni faktor 2 kinaza
Elongacioni faktor 2 kinaza (EC 2.7.11.20, Ca/CaM-kinaza III, kalmodulin-zavisni protein kinaza III, CaM kinaza III, eEF2 kinaza, eEF2K, EF2K, STK19) je enzim sa sistematskim imenom ATP:(elongacioni faktor 2) fosfotransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Elongacioni faktor 2 kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.11.20 | ||||||||
| CAS broj | 116283-83-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Za rad ovog enzima je neophodan jon Ca2+ i kalmodulin.
Reference uredi
- ↑ Mitsui, K., Brady, M., Palfrey, H.C. and Nairn, A.C. (1993). „Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas”. J. Biol. Chem. 268: 13422-13433. PMID 8514778.
- ↑ Hincke, M.T. and Nairn, A.C. (1992). „Phosphorylation of elongation factor 2 during Ca2+-mediated secretion from rat parotid acini”. Biochem. J. 282: 877-882. PMID 1372803.
- ↑ Knebel, A., Morrice, N. and Cohen, P. (2001). „A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta”. EMBO J. 20: 4360-4369. PMID 11500363.
- ↑ Sans, M.D., Xie, Q. and Williams, J.A. (2004). „Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini”. Biochem. Biophys. Res. Commun. 319: 144-151. PMID 15158453.
- ↑ Browne, G.J., Finn, S.G. and Proud, C.G. (2004). „Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398”. J. Biol. Chem. 279: 12220-12231. PMID 14709557.
- ↑ Ryazanov, A.G. (2002). „Elongation factor-2 kinase and its newly discovered relatives”. FEBS Lett. 514: 26-29. PMID 11904175.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.