Dihidrolipoilizin-ostatak acetiltransferaza
Dihidrolipoilizin-ostatak acetiltransferaza (EC 2.3.1.12, acetil-KoA:dihidrolipoamidna S-acetiltransferaza, dihidrolipoamidna S-acetiltransferaza, dihidrolipoatna acetiltransferaza, dihidrolipoinska transacetilaza, dihidrolipoilna acetiltransferaza, lipoatna acetiltransferaza, lipoatna transacetilaza, lipoinska acetiltransferaza, lipoinska kiselina acetiltransferaza, lipoinska transacetilaza, lipoilacetiltransferaza, tioltransacetilaza A, transacetilaza X, enzim-dihidrolipoillizin:acetil-KoA S-acetiltransferaza, acetil-KoA:enzim 6-N-(dihidrolipoil)lizin S-acetiltransferaza) je enzim sa sistematskim imenom acetil-KoA:enzim N6-(dihidrolipoil)lizin S-acetiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dihidrolipoilizin-ostatak acetiltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.3.1.12 | ||||||||
| CAS broj | 9032-29-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- acetil-KoA + enzim N6-(dihidrolipoil)lizin KoA + enzim N6-(S-acetildihidrolipoil)lizin
Multimer (24-mer ili 60-mer, u zavisnosti od izvora) ovog enzima formira osnovu piruvat dehidrogenaznog multienzimskog kompleksa.
Reference uredi
- ↑ Brady, R.O. and Stadtman, E.R. (1954). „Enzymatic thioltransacetylation”. J. Biol. Chem. 211: 621-629. PMID 13221570.
- ↑ Gunsalus, I.C. (1954). „Group transfer and acyl-generating functions of lipoic acid derivatives”. u: McElroy, W.D. and Glass, B.. A Symposium on the Mechanism of Enzyme Action. Baltimore: Johns Hopkins Press. str. 545-580.
- ↑ Gunsalus, I.C., Barton, L.S. and Gruber, W. (1956). „Biosynthesis and structure of lipoic acid derivatives”. J. Am. Chem. Soc. 78: 1763-1766.
- ↑ Perham, R.N. (2000). „Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions”. Annu. Rev. Biochem. 69: 961-1004. PMID 10966480.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Gunsalus, I.C. (1954). „Group transfer and acyl-generating functions of lipoic acid derivatives”. u: McElroy, W.D. and Glass, B.. A Symposium on the Mechanism of Enzyme Action. Baltimore: Johns Hopkins Press. str. 545-580.