Protein-lizin 6-oksidaza

(Preusmjereno sa EC 1.4.3.13)

Protein-lizin 6-oksidaza (EC 1.4.3.13, lizil oksidaza) je enzim sa sistematskim imenom protein-L-lizin:kiseonik 6-oksidoreduktaza (deaminacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Protein-lizin 6-oksidaza
Identifikatori
EC broj 1.4.3.13
CAS broj 99676-44-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures
peptidil-L-lizil-peptid + O2 + H2O peptidil-alizil-peptid + NH3 +H2O2

On takođe deluje na protein 5-hidroksilizin. Ovaj enzim katalizuje final enzimski korak unakrsnog povezivanja kolagena i elastina u biosintezi normalnog odraslog ekstracelularnog matriksa.

ReferenceUredi

  1. Harris, E.D., Gonnerman, W.A., Savage, J.E. and O'Dell, B.L. (1974). "Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta". Biochim. Biophys. Acta 341: 332–344. PMID 4838158. 
  2. Rayton, J.K. and Harris, E.D. (1979). "Induction of lysyl oxidase with copper. Properties of an in vitro system". J. Biol. Chem. 254: 621–626. PMID 33171. 
  3. Stassen, F.L.H. (1976). "Properties of highly purified lysyl oxidase from embryonic chick cartilage". Biochim. Biophys. Acta 438: 49–60. PMID 7318. 
  4. Palamakumbura, A.H. and Trackman, P.C. (2002). "A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples". Anal. Biochem. 300: 245–251. PMID 11779117. 
  5. Kagan, H.M., Williams, M.A., Williamson, P.R. and Anderson, J.M. (1984). "Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates". J. Biol. Chem. 259: 11203–11207. PMID 6147351. 

LiteraturaUredi

Spoljašnje vezeUredi