Dihidropteroat sintaza
(Preusmjereno sa stranice Dihidropteroat sintetaza)
Dihidropteroat sintaza (EC 2.5.1.15, dihidropteroat pirofosforilaza, DHPS, 7,8-dihidropteroat sintaza, 7,8-dihidropteroat sintetaza, 7,8-dihidropteroinska kiselina sintetaza, dihidropteroat sintetaza, dihidropteroinska sintetaza, 2-amino-4-hidroksi-6-hidroksimetil-7,8-dihidropteridin-difosfat:4-aminobenzoat 2-amino-4-hidroksidihidropteridin-6-meteniltransferaza) je enzim sa sistematskim imenom (2-amino-4-hidroksi-7,8-dihidropteridin-6-il)metil-difosfat:4-aminobenzoat 2-amino-4-hidroksidihidropteridin-6-meteniltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dihidropteroat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Dihidropteroat sintaza homodimer, Bacillus anthracis | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.5.1.15 | ||||||||
| CAS broj | 9055-61-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (2-amino-4-hidroksi-7,8-dihidropteridin-6-il)metil difosfat + 4-aminobenzoat difosfat + 7,8-dihidropteroat
Reference uredi
- ↑ Richey, D.P. and Brown, G.M. (1969). „The biosynthesis of folic acid. IX. Purification and properties of the enzymes required for the formation of dihydropteroic acid”. J. Biol. Chem. 244: 1582-1592. PMID 4304228.
- ↑ Shiota, T., Baugh, C.M., Jackson, R. and Dillard, R. (1969). „The enzymatic synthesis of hydroxymethyldihydropteridine pyrophosphate and dihydrofolate”. Biochemistry 8: 5022-5028. PMID 4312465.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.