Dicikloverin

Dicikloverin
(IUPAC) ime
	2-(dietilamino)etil bi(cikloheksan)-1-karboksilat
Klinički podaci
Robne marke	Biklomin, Bentil, Dibent, Di-Spaz, Dilomin
AHFS/Drugs.com	Internacionalno ime leka
MedlinePlus	a684007
Identifikatori
CAS broj	77-19-0
ATC kod	A03AA07
PubChem	3042
DrugBank	APRD00113
ChemSpider	2934
UNII	4KV4X8IF6V
KEGG	D07820
ChEBI	CHEBI:4514
ChEMBL	CHEMBL1123
Hemijski podaci
Formula	C19H35NO2
Mol. masa	309,487 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3 ; Key: CURUTKGFNZGFSE-UHFFFAOYSA-N
Farmakokinetički podaci
Vezivanje za proteine plazme	>99%
Poluvreme eliminacije	5 h
Farmakoinformacioni podaci
Trudnoća	B(US)
Pravni status

Diciklomin (dicikloverin) je antiholinergik koji blokira muskarinske receptore. Dicikloverin je prvi put bio sintetisan u SAD-u tokom 1947.

Medicinske upotrebe

Dicikloverin se koristi za lečenje intestinalne hipermotilnosti, simptoma sindroma iritabilnog kolona (IBS). On olakšava mišićne spazme i grčeve u gastrointestinalnom traktu putem blokiranja aktivnosti acetilholina na holinergijskim (ili muskarinskim) receptorima na površini mišićnih ćelija. On je relaksant glatkih mišića.^[6]

Dicikloverin je u prodaji pod nekoliko trgovačkih imena.^[7] U Ujedinjenom Kraljevstvu, on je sastojak preparata Kolantikon, zajedno sa antiflatulentom (simetikon) i dva antacida. On se takođe prodaje kao analgetik i spasmolitik pod imenom Meftal-SPAS, koji sadrži mefenaminsku kiselinu, zajedno sa diciklomin hidrohloridom.

Nepoželjne pojave

Diciklomin može da uzrokuje brojne antiholinergijske nuspojave kao što su suva usta i mučnina, a pri višim dozama delirijantni efekti.^[6] Rekreaciona upotreba ovog leka je veoma retka.^[6]^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ ^6,0 ^6,1 ^6,2 „Dicyclomine hydrochloride”. Monograph. Drugs.com.
↑ „Dicycloverine”. International drug names. Drugs.com.
↑ Carlini E. A. (1993). „Preliminary note: dangerous use of anticholinergic drugs in Brazil”. Drug and Alcohol Dependence 32 (1): 1–7. DOI:10.1016/0376-8716(93)90016-J. PMID 8486081.

Literatura

{{refbegin|2}{

Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4

}-

Vanjske veze

	Portal Medicina
	Portal Hemija

„Dicyclomine”. Medicine Net.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[mono-6] 6,0 ^6,1 ^6,2 „Dicyclomine hydrochloride”. Monograph. Drugs.com.

[7] „Dicycloverine”. International drug names. Drugs.com.

[8] Carlini E. A. (1993). „Preliminary note: dangerous use of anticholinergic drugs in Brazil”. Drug and Alcohol Dependence 32 (1): 1–7. DOI:10.1016/0376-8716(93)90016-J. PMID 8486081.

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