Diacilglicerol lipaza
Diacolglocerol lipaza (DAG lipaza, DAGL, DGL) je ključni enzim u biosintezi endokanabinoida 2-arahidonoilglicerol.[1] On katalizuje hidrolizu diacilglicerola, otpuštanjem slobodne masne kiseline i monoacilglicerola.
| Diacilglicerol lipaza, alfa | |
|---|---|
| Identifikatori | |
| Simbol | DAGLA |
| Alt. simboli | C11orf11 |
| Entrez | 747 |
| Hugo | 1165 |
| RefSek | NM_006133 |
| UniProt | Q9Y4D2 |
| Drugi podaci | |
| EC broj | 3.1.1.- |
| Lokus | Hrom. 11 q12.3 |
| Diacilglicerol lipaza, beta | |
|---|---|
| Identifikatori | |
| Simbol | DAGLB |
| Entrez | 221955 |
| Hugo | 28923 |
| RefSek | NM_139179 |
| UniProt | Q8NCG7 |
| Drugi podaci | |
| EC broj | 3.1.1.- |
| Lokus | Hrom. 7 p22.1 |
Dva zasebna gena koji kodiraju DGL enzime su klonirana, DGLα (DAGLA) i DGLβ (DAGLB). Oni imaju 33% identične sekvence.
Inhibitori uredi
Ovaj enzim selektivno inhibiraju RHC80267 i tetrahidrolipstatin.
Reference uredi
- ↑ Bisogno T, Howell F, Williams G, et al. (November 2003). „Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain”. J. Cell Biol. 163 (3): 463–8. DOI:10.1083/jcb.200305129. PMC 2173631. PMID 14610053.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.