Detiobiotinska sintaza
Detiobiotinska sintaza (EC 6.3.3.3, destiobiotinska sintaza) je enzim sa sistematskim imenom 7,8-diaminononanoat:karbon-dioksid ciklo-ligaza (formira ADP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Detiobiotinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.3.3 | ||||||||
| CAS broj | 37259-75-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + 7,8-diaminononanoat + CO2 ADP + fosfat + detiobiotin
CTP ima polovinu aktivnosti ATP molekula.
Reference
uredi- ↑ Krell, K. and Eisenberg, M.A. (1970). „The purification and properties of dethiobiotin synthetase”. J. Biol. Chem. 245: 6558-6566. PMID 4921568.
- ↑ Yang, H.-C., Tani, Y. and Ogata, K. (1970). „Synthesis of biotin vitamers from biotin diaminocarboxylic acid or 7,8-diaminopelargonic acid by a purified enzyme of Pseudomonas graveolens”. Agric. Biol. Chem. 34: 1748-1750.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.