Demetilrebekamicin-D-glukoza O-metiltransferaza
Demetilrebekamicin-D-glukoza O-metiltransferaza (EC 2.1.1.164, RebM) je enzim sa sistematskim imenom S-adenozil-L-metionin:demetilrebekamicin-D-glukoza O-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Demetilrebekamicin-D-glukoza O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.164 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4'-demetilrebekmicin + S-adenozil-L-metionin rebekamicin + S-adenozil-L-homocistein
Ovaj enzim katalizuje zadnji korak biosinteze rebekamicina, indolokarbazolnog alkaloida koji formira actinobakterija Lechevalieria aerocolonigenes.
Reference uredi
- ↑ Zhang, C., Albermann, C., Fu, X., Peters, N.R., Chisholm, J.D., Zhang, G., Gilbert, E.J., Wang, P.G., Van Vranken, D.L. and Thorson, J.S. (2006). „RebG- and RebM-catalyzed indolocarbazole diversification”. Chembiochem 7: 795-804. PMID 16575939.
- ↑ Singh, S., McCoy, J.G., Zhang, C., Bingman, C.A., Phillips, G.N., Jr. and Thorson, J.S. (2008). „Structure and mechanism of the rebeccamycin sugar 4′-O-methyltransferase RebM”. J. Biol. Chem. 283: 22628-22636. PMID 18502766.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.