Defibrotid
Defibrotid je natrimova so smeše jednolančanih oligodezoksiribonukleotida izvedenih iz DNK svinjske sluzokože ili goveđih pluća. Defibrotid ima antitrombotska, antiinflamatorna i antiishemijska svojstva (bez znatnih sistemskih antikoagulantskih efekata). On je u prodaji pod imenima: Dasovas (FM), Noravid, i Prociclide.[1][2][3][4][5][6][7][8]
| Klinički podaci | |
|---|---|
| Robne marke | Dasovas, Noravid, Prociclide |
| AHFS/Drugs.com | Monografija |
| Identifikatori | |
| CAS broj | 83712-60-1 |
| ATC kod | B01AX01 |
| DrugBank | DB04932 |
| Hemijski podaci | |
| Formula | ? |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 10-20 minuta |
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | |
| Način primene | Intramaskularno, oralno |
Reference uredi
- ↑ Noseda G, Fragiacomo C, Ferrari D: Pharmacokinetics of defibrotide in healthy volunteers. Haemostasis. 1986;16 Suppl 1:26-30. PMID 3754833
- ↑ Palmer KJ, Goa KL: Defibrotide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in vascular disorders. Drugs. 1993 Feb;45(2):259-94. PMID 7681375
- ↑ Fisher J, Johnston AM, Holland TK, McCallum J, Pescador R, Mantovani M, Prino G: Pharmacokinetics, absorption, distribution and disposition of [125I]-defibrotide following intravenous or oral administration in the rat. Thromb Res. 1993 Apr 1;70(1):77-90. PMID 8511753
- ↑ Koehl GE, Geissler EK, Iacobelli M, Frei C, Burger V, Haffner S, Holler E, Andreesen R, Schlitt HJ, Eissner G: Defibrotide: An Endothelium Protecting and Stabilizing Drug, has an Anti-Angiogenic Potential In Vitro and In Vivo. Cancer Biol Ther. 2007 May;6(5):686-90. Epub 2007 Feb 3. PMID 17495522
- ↑ Kornblum N, Ayyanar K, Benimetskaya L, Richardson P, Iacobelli M, Stein CA: Defibrotide, a polydisperse mixture of single-stranded phosphodiester oligonucleotides with lifesaving activity in severe hepatic veno-occlusive disease: clinical outcomes and potential mechanisms of action. Oligonucleotides. 2006 Spring;16(1):105-14. PMID 16584299
- ↑ Pescador R, Porta R, Ferro L: An integrated view of the activities of defibrotide. Semin Thromb Hemost. 1996;22 Suppl 1:71-5. PMID 8807733
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
Literatura uredi
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.
