DNK-metiltransferaza (citozin-N4-specifična)
DNK-metiltransferaza (citozin-N4-specifična) (EC 2.1.1.113, modifikaciona metilaza, restrikciono-modifikacioni sistem, DNK(citozin-N4)metiltransferaza, Mtase (formira m4C), S-adenozil-L-metionin:DNK-citozin 4-N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:DNK-citozin N4-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| DNK-metiltransferaza (citozin-N4-specifična) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.113 | ||||||||
| CAS broj | 169592-50-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ovao je velika grupa enzima, većina kojih ima sličnu specifičnost sa enzimima grupa EC 3.1.21.3, EC 3.1.21.4 i EC 3.1.21.5.
Reference uredi
- ↑ Kessler, C. and Manta, V. (1990). „Specificity of restriction endonucleases and DNA modification methyltransferases: a review”. Gene 92: 1-248. PMID 2172084.
- ↑ Klimasauskas, S., Timinskas, A., Menkevicius, S., Butkiene, D., Butkus, V. and Janulaitis, A. (1989). „Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases”. Nucleic Acids Res. 17: 9823-9832. PMID 2690010.
- ↑ Roberts, R.J. (1990). „Restriction enzymes and their isoschizomers”. Nucleic Acids Res. 18: 2331-2365. PMID 2159140.
- ↑ Yuan, R. (1981). „Structure and mechanism of multifunctional restriction endonucleases”. Annu. Rev. Biochem. 50: 285-319. PMID 6267988.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.