DCPG ((S)-3,4-DCPG) je lek koji se koristi u naučnim istraživanjima. On deluje kao potentan i selektivan agonist za metabotropni glutamatni receptor mGluR8. On ima antikonvulzivno dejstvo u životinjskim studijama.[3][4] On je takođe istraživan kao mogući tretman za hiperalgeziju.[5]
DCPG
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| (IUPAC) ime
|
| 4-[(1S)-1-amino-2-hidroksi-2-oksoetil]ftalna kiselina
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| Klinički podaci
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| Identifikatori
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| CAS broj
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201730-11-2
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| ATC kod
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nije dodeljen
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| PubChem[1][2]
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16062593
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| Hemijski podaci
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| Formula
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C10H9NO6
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| Mol. masa
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239,181 g/mol
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1  Y
Key: IJVMOGKBEVRBPP-ZETCQYMHSA-N Y |
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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|
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Moldrich RX, Chapman AG, De Sarro G, Meldrum BS. Glutamate metabotropic receptors as targets for drug therapy in epilepsy. European Journal of Pharmacology. 2003 Aug 22;476(1-2):3-16. DOI:10.1016/S0014-2999(03)02149-6 PMID 12969743
- ↑ Folbergrová J, Druga R, Haugvicová R, Mares P, Otáhal J. Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid. Neuropharmacology. 2008 Mar;54(4):665-75. PMID 18191956
- ↑ Marabese I, de Novellis V, Palazzo E, Scafuro MA, Vita D, Rossi F, Maione S. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology. 2007 Feb;52(2):253-62. PMID 17113112
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