Citikolin (citidin difosfat-holin, CDP-holin, citidin 5'-difosfoholin) je psihostimulans/nutropik. On je intermedijar u generaciji fosfatidilholina iz holina.

Citikolin
(IUPAC) ime
5'-O-[hidroksi({hidroksi[2-(trimetilamonio)etoksi]
fosforil}oksi)fosforil]citidin
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 987-78-0
ATC kod N06BX06
PubChem[1][2] 13805
ChemSpider[3] 16736209
UNII 536BQ2JVC7 YesY
KEGG[4] D00057 YesY
ChEMBL[5] CHEMBL1618340 YesY
Hemijski podaci
Formula C14H27N4O11P2+
Mol. masa 489,332 g/mol
SMILES eMolekuli & PubHem
Sinonimi Cytidine diphosphate choline
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Ispitivanja sugerišu da CDP-holin suplementi povećavaju gustine dopaminskog receptora,[6] i da pomažu u sprečavanju gubljenja memorije uzrokovanog lošim uslovima životne sredine.[7] Preliminarna ispitivanja su utvrdila da citikolinski suplementi pomažu u poboljšanju fokusa i mentalne energije, te da potencijalno mogu da budu korisni u tretmanu deficita koncentracije.[8][9] Citikolin isto tako povišava nivo ACTH-a nezavisno od nivoa CRH.[10]

ReferenceUredi

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. Giménez R, Raïch J, Aguilar J (November 1991). „Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice”. British Journal of Pharmacology 104 (3): 575–8. PMC 1908237. PMID 1839138. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1908237/. 
  7. Teather LA, Wurtman RJ (2005). „Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats”. Learning & Memory 12 (1): 39–43. DOI:10.1101/lm.83905. PMC 548494. PMID 15647594. //www.ncbi.nlm.nih.gov/pmc/articles/PMC548494/. 
  8. „Supplement naturally boosts ageing brain power”. Sydney Morning Herald. 25. 02. 2008.. http://www.smh.com.au/articles/2008/02/24/1203788130776.html. Pristupljeno 28. 07. 2009. 
  9. Silveri MM, Dikan J, Ross AJ, et al. (November 2008). „Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy”. NMR in Biomedicine 21 (10): 1066–75. DOI:10.1002/nbm.1281. PMID 18816480. 
  10. Cavun S, Savci V (October 2004). „CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement”. Fundamental & Clinical Pharmacology 18 (5): 513–23. DOI:10.1111/j.1472-8206.2004.00272.x. PMID 15482372. 

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