Ciklopropan-masni-acil-fosfolipid sintaza
Ciklopropan-masni-acil-fosfolipid sintaza (EC 2.1.1.79, ciklopropanska sintetaza, nezasićena-fosfolipidna metiltransferaza, ciklopropanska sintaza, ciklopropan masno kiselinska sintaza, ciklopropan masna kiselina sintetaza, CFA sintaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:nezasićeni-fosfolipid metiltransferaza (ciklizacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Ciklopropan-masni-acil-fosfolipid sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.79 | ||||||||
| CAS broj | 51845-48-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + fosfolipid olefinska masna kiselina S-adenozil-L-homocistein + fosfolipid ciklopropan masna kiselina
Ovaj enzim dodaje metilin grupu u 9,10 pozicijama Delta9-olefinskog kiselinskog lanca u fosfatidiletanolaminu.
Reference uredi
- ↑ Chung, A.E. and Law, J.H. (1964). „Cyclopropane fatty acid synthetase: Partial purification and properties”. Biochemistry 3: 967-974. PMID 14214089.
- ↑ Zalkin, H., Law, J.H. and Goldfine, H. (1963). „Enzymatic synthesis of cyclopropane fatty acids catalyzed by bacterial extracts”. J. Biol. Chem. 238: 1242-1248. PMID 14003136.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.