Cikloastragenol

Cikloastragenol
Drugi nazivi	Ciklogalegigenin, Astramembrangenin, TA-65
Identifikacija
CAS registarski broj	4605-18-5
PubChem	44144539
Jmol-3D slike	Slika 1
SMILES
	CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]3[C@@H](O)C[C@@]2(C)[C@@H]4C[C@H](O)[C@H]6[C@](C)(C)[C@@H](O)CC[C@@]65C[C@@]45CC[C@@]23C
InChI
	InChI=1S/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21-,22-,23-,26+,27-,28+,29-,30+/m0/s1 ; Kod: WENNXORDXYGDTP-UOUCMYEWSA-N
Svojstva
Molekulska formula	C30H50O5
Molarna masa	490,72 g/mol
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Cikloastragenol je sapogenin koji je prisutan u biljci Astragalus membranaceus.^[3] On je u prodaji pod imenima TA-65 ili TA-65MD u SAD-u. Proizvodi ga kompanija Telomerase Activation Sciences, Inc.. TA-65 se pojavio na tržištu 2005.

Cikloastragenol umereno povećava aktivnost telomeraze i proliferativni kapacitet CD4 i CD8 T ćelija.^[4] Postoje indikacije da je on posebno efektivan kod citomegalovirus-pozitivnih osoba.^[5]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Fauce, SR; Jamieson, BD; Chin, AC; Mitsuyasu, RT; Parish, ST; Ng, HL; Kitchen, CM; Yang, OO et al. (2008). „Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes”. Journal of immunology 181 (10): 7400–6. PMC 2682219. PMID 18981163.
↑ Valenzuela, Hector F; Fuller, Thomas; Edwards, Jim; Finger, Danielle; Molgora, Brenda (2009). „Cycloastragenol extends T cell proliferation by increasing telomerase activity”. The Journal of Immunology 182 (Meeting Abstract Supplement).
↑ Harley, Calvin B; Liu, Weimin; Blasco, Maria; Vera, Elsa; Andrews, William H; Briggs, Laura A; Raffaele, Joseph M (2011-01-02). „A Natural Product Telomerase Activator As Part of a Health Maintenance Program”. Rejuvenation Research 14 (1): 45–56. DOI:10.1089/rej.2010.1085.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Fauce, SR; Jamieson, BD; Chin, AC; Mitsuyasu, RT; Parish, ST; Ng, HL; Kitchen, CM; Yang, OO et al. (2008). „Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes”. Journal of immunology 181 (10): 7400–6. PMC 2682219. PMID 18981163.

[4] Valenzuela, Hector F; Fuller, Thomas; Edwards, Jim; Finger, Danielle; Molgora, Brenda (2009). „Cycloastragenol extends T cell proliferation by increasing telomerase activity”. The Journal of Immunology 182 (Meeting Abstract Supplement).

[5] Harley, Calvin B; Liu, Weimin; Blasco, Maria; Vera, Elsa; Andrews, William H; Briggs, Laura A; Raffaele, Joseph M (2011-01-02). „A Natural Product Telomerase Activator As Part of a Health Maintenance Program”. Rejuvenation Research 14 (1): 45–56. DOI:10.1089/rej.2010.1085.

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