CY-208,243 je lek koji deluje kao selektivni dopaminski agonist za D1 podtipe. Za razliku od većene D1-selektivnih agonista, on je pokazao efikasnot u životinjskim modelima za Parkinsonovu bolest.[3][4][5][6][7]
CY-208243
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| (IUPAC) ime
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| 4,6,6a,7,8,12b-heksahidro-7-metilindolo(4,3-ab)-fenantridin
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| Klinički podaci
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| Identifikatori
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| CAS broj
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100999-26-6
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| ATC kod
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nije dodeljen
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| PubChem[1][2]
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58144
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| Hemijski podaci
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| Formula
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C19H18N2
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| Mol. masa
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274,359 g/mol
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C19H18N2/c1-21-11-12-5-2-3-6-14(12)19-15-7-4-8-16-18(15)13(10-20-16)9-17(19)21/h2-8,10,17,19-20H,9,11H2,1H3  Y
Key: WRNKIDLXXXIELU-UHFFFAOYSA-N Y |
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Gagnon C, Gomez-Mancilla B, Markstein R, Bédard PJ, Di Paolo T (July 1995). „Effect of adding the D-1 agonist CY 208-243 to chronic bromocriptine treatment of MPTP-monkeys: regional changes of brain dopamine receptors”. Progress in Neuro-psychopharmacology & Biological Psychiatry 19 (4): 667–76. PMID 8588064.
- ↑ Beninger RJ, Rolfe NG (December 1995). „Dopamine D1-like receptor agonists impair responding for conditioned reward in rats”. Behavioural Pharmacology 6 (8): 785–793. PMID 11224381.
- ↑ Luquin MR, Guillén J, Legarda I, Cruz Rodriguez M, Del Rio L, Dominguez J, Martínez-Lage JM (1996). „Pulsatile administration of D1 but not D2 dopamine agonists induces behavioral tolerance in MPTP-treated monkeys”. Advances in Neurology 69: 239–44. PMID 8615134.
- ↑ D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G (January 2003). „Dopamine D1 receptor agonists induce penile erections in rats”. European Journal of Pharmacology 460 (1): 71–4. DOI:10.1016/S0014-2999(02)02881-9. PMID 12535862.
- ↑ Salamone JD, Carlson BB, Rios C, Lentini E, Correa M, Wisniecki A, Betz A (January 2005). „Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243”. Behavioural Brain Research 156 (2): 173–9. DOI:10.1016/j.bbr.2004.05.019. PMID 15582103.
