Bradikininski receptor B1

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Bradikininski receptor B1 (B₁) je G-protein spregnuti receptor kodiran BDKRB1 genom kod ljudi. Njegov principalni ligand je bradikinin, peptid sa 9 aminokiselina koji se formira u patofiziološkim uslovima kao što je inflamacija, trauma, opekotine, šok, i alergija. B₁ receptor je jedan od dva G protein-spregnuta receptora za koje je utvrđeno da vezuju bradikinin i posreduju response na te patofiziološke uslove.

Bradikininski receptor B1
Identifikatori
Simboli	BDKRB1; B1BKR; B1R; BKB1R; BKR1; BRADYB1
Vanjski ID	OMIM: 600337 MGI: 88144 HomoloGene: 570 IUPHAR: B1 GeneCards: BDKRB1 Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • aktivnost bradikininskog receptora Celularna komponenta • endoplazmatični retikulum • ćelijska membrana • integralno sa ćelijskom membranom Biološki proces • inflamatorni respons • prenos signala • signalni put G-protein spregnutog receptora • elevacija koncentracije citosolnih jona kalcijuma
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	623	12061
Ensembl	ENSG00000100739	ENSMUSG00000041347
UniProt	P46663	Q0VBD7
RefSeq (mRNA)	NM_000710	NM_007539
RefSeq (protein)	NP_000701	NP_031565
Lokacija (UCSC)	Chr 14: 95.8 - 95.8 Mb	Chr 12: 106.01 - 106.01 Mb
PubMed pretraga	[1]	[2]

B₁ protein se sintetiše de novo nakon povrede tkiva. Njegovo vezivanje za receptor dovodi do povećanja citosolne koncentracije jona kalcijuma, što ultimatno dovodi do hroničnog i akutnog inflamatornog responsa.

Literatura

• Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A (2007). „A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5.”. J. Immunol. 179 (7): 4849–56. PMID 17878384. 
• Calixto JB, Medeiros R, Fernandes ES, et al. (2005). „Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes.”. Br. J. Pharmacol. 143 (7): 803–18. DOI:10.1038/sj.bjp.0706012. PMC 1575942. PMID 15520046. 
• Menke JG, Borkowski JA, Bierilo KK, et al. (1994). „Expression cloning of a human B1 bradykinin receptor.”. J. Biol. Chem. 269 (34): 21583–6. PMID 8063797. 
• Yang X, Polgar P (1996). „Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions.”. Biochem. Biophys. Res. Commun. 222 (3): 718–25. DOI:10.1006/bbrc.1996.0810. PMID 8651911. 
• Bachvarov DR, Hess JF, Menke JG, et al. (1996). „Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1).”. Genomics 33 (3): 374–81. DOI:10.1006/geno.1996.0213. PMID 8660997. 
• Chai KX, Ni A, Wang D, et al. (1996). „Genomic DNA sequence, expression, and chromosomal localization of the human B1 bradykinin receptor gene BDKRB1.”. Genomics 31 (1): 51–7. DOI:10.1006/geno.1996.0008. PMID 8808279. 
• Leeb T, Mathis SA, Leeb-Lundberg LM (1997). „The sixth transmembrane domains of the human B1 and B2 bradykinin receptors are structurally compatible and involved in discriminating between subtype-selective agonists.”. J. Biol. Chem. 272 (1): 311–7. DOI:10.1074/jbc.272.1.311. PMID 8995263. 
• Blaukat A, Herzer K, Schroeder C, et al. (1999). „Overexpression and functional characterization of kinin receptors reveal subtype-specific phosphorylation.”. Biochemistry 38 (4): 1300–9. DOI:10.1021/bi981727r. PMID 9930991. 
• Cassano G, Susca F, Lippe C, Guanti G (1999). „Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts.”. Gen. Pharmacol. 32 (2): 239–44. DOI:10.1016/S0306-3623(98)00275-4. PMID 10188626. 
• Zhou X, Prado GN, Chai M, et al. (2000). „Posttranscriptional destabilization of the bradykinin B1 receptor messenger RNA: cloning and functional characterization of the 3'-untranslated region.”. Mol. Cell Biol. Res. Commun. 1 (1): 29–35. DOI:10.1006/mcbr.1999.0105. PMID 10329474. 
• Jones C, Phillips E, Davis C, et al. (1999). „Molecular characterisation of cloned bradykinin B1 receptors from rat and human.”. Eur. J. Pharmacol. 374 (3): 423–33. DOI:10.1016/S0014-2999(99)00315-5. PMID 10422787. 
• Sjuve R, Boels PJ, Uvelius B, Arner A (2000). „Up-regulation of bradykinin response in rat and human bladder smooth muscle.”. J. Urol. 164 (5): 1757–63. DOI:10.1016/S0022-5347(05)67102-9. PMID 11025765. 
• Sawant S, Snyman C, Bhoola K (2002). „Comparison of tissue kallikrein and kinin receptor expression in gastric ulcers and neoplasms.”. Int. Immunopharmacol. 1 (12): 2063–80. DOI:10.1016/S1567-5769(01)00118-7. PMID 11710536. 
• Ignjatovic T, Tan F, Brovkovych V, et al. (2002). „Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor.”. J. Biol. Chem. 277 (19): 16847–52. DOI:10.1074/jbc.M200355200. PMID 11880373. 
• Newton R, Eddleston J, Haddad el-B, et al. (2002). „Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone.”. Eur. J. Pharmacol. 441 (3): 193–202. DOI:10.1016/S0014-2999(01)01624-7. PMID 12063092. 
• Kang DS, Leeb-Lundberg LM (2002). „Negative and positive regulatory epitopes in the C-terminal domains of the human B1 and B2 bradykinin receptor subtypes determine receptor coupling efficacy to G(q/11)-mediated [correction of G(9/11)-mediated] phospholipase Cbeta activity.”. Mol. Pharmacol. 62 (2): 281–8. DOI:10.1124/mol.62.2.281. PMID 12130679. 
• Christiansen SC, Eddleston J, Woessner KM, et al. (2002). „Up-regulation of functional kinin B1 receptors in allergic airway inflammation.”. J. Immunol. 169 (4): 2054–60. PMID 12165532. 
• Lamb ME, Zhang C, Shea T, et al. (2003). „Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells.”. Biochemistry 41 (48): 14340–7. DOI:10.1021/bi020231d. PMID 12450400. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Kang DS, Ryberg K, Mörgelin M, Leeb-Lundberg LM (2004). „Spontaneous formation of a proteolytic B1 and B2 bradykinin receptor complex with enhanced signaling capacity.”. J. Biol. Chem. 279 (21): 22102–7. DOI:10.1074/jbc.M402572200. PMID 15033977. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 

Vidi još

• Bradikininski receptor

Spoljašnje veze

• „Bradykinin Receptors: B₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.