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Binospiron

Binospiron (MDL-73,005-EF) je lek koji deluje kao parcijalni agonist na 5-HT1A somatodendritiskim autoreceptorima, i kao antagonist na postsinaptičkim 5-HT1A receptorima.[4] On ima anksiolitsko dejstvo.[5]

Binospiron
(IUPAC) ime
8-[2-(2,3-dihidro-1,4-benzodioksin-2-ilmetilamino)etil]-8-azaspiro[4.5]dekan-7,9-dion
Klinički podaci
Identifikatori
CAS broj 124756-23-6
ATC kod nije dodeljen
PubChem[1][2] 60769
ChemSpider[3] 54766
UNII T3M5D109V5 DaY
Hemijski podaci
Formula C20H26N2O4 
Mol. masa 358,431 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Reference uredi

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Bertrand, F; Lehmann, O; Galani, R; Lazarus, C; Jeltsch, H; Cassel, JC (2001). „Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats”. Pharmacology, Biochemistry, and Behavior 68 (4): 647–60. DOI:10.1016/S0091-3057(01)00448-8. PMID 11526961. 
  5. ↑ Moser, PC; Tricklebank, MD; Middlemiss, DN; Mir, AK; Hibert, MF; Fozard, JR (1990). „Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam”. British Journal of Pharmacology 99 (2): 343–9. PMC 1917389. PMID 1970269. 

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