Benzatropin
Benzatropin (INN, benztropin) je antiholinergik koji je u prodaji pod imenom Kogentin. Koristi se za tretman Parkinsonove bolesti, parkinsonizma, i distonije.[5][6]
| |||
| (IUPAC) ime | |||
|---|---|---|---|
| (3-endo)-3-(difenilmetoksi)-8-metil-8-azabiciklo[3.2.1]oktan | |||
| Klinički podaci | |||
| Robne marke | Cogentin | ||
| AHFS/Drugs.com | Monografija | ||
| Identifikatori | |||
| CAS broj | 86-13-5 | ||
| ATC kod | N04AC01 | ||
| PubChem[1][2] | 1201549 | ||
| DrugBank | DB00245 | ||
| ChemSpider[3] | 16736541 | ||
| UNII | 1NHL2J4X8K  | ||
| ChEBI | CHEBI:3048 | ||
| ChEMBL[4] | CHEMBL1201203 | ||
| Hemijski podaci | |||
| Formula | C21H25NO | ||
| Mol. masa | 307,429 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | C(US) | ||
| Pravni status | |||
| Način primene | Oralno, IM, IV | ||
Medicinska upotreba uredi
Benztropin je antiholinergički lek koji se koristi za redukovanje nuspojava antipsihotičkog tretmana, kao što je pseudoparkinsonizam i distonija.
Hemija uredi
Benztropin, 3-(difenilmetoksi)tropan, se može sintetisati reakcijom tropina i difenildiazometana.[7]
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- ↑ Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0.
- ↑ R.F. Phillips, N.J. Westfield, U.S. Patent 2.595.405 (1952).
