BQ-123

BQ-123
	2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
Drugi nazivi	Ciklo(D-trp-D-asp-L-pro-D-val-L-leu)
Identifikacija
CAS registarski broj	136553-81-6
PubChem	443289
ChEMBL	CHEMBL1269102
IUPHAR ligand	997
Jmol-3D slike	Slika 1
SMILES
	CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43
InChI
	InChI=1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1 ; Kod: VYCMAAOURFJIHD-PJNXIOHISA-N
Svojstva
Molekulska formula	C31H42N6O7
Molarna masa	610.7 g mol−1
Opasnost
S-oznake	S22 S24/25
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

BQ-123 je ciklični peptid koji sadrži pet aminokiselina. Njegova aminokiselinska sekvenca je D-triptamin-D-Asparaginska kiselina- L -prolin- D-valin-L-leucin.^[4]

BQ-123 je selektivni antagonist endotelinkog receptora‎‎ ET_A. On se koristi kao biohemijsko oruđe za ispitivanje funkcija endotelinskog receptora.

Literatura uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Bonvallet ST, Oka M, Yano M, Zamora MR, McMurtry IF, Stelzner TJ (1993). „BQ123, an ETA receptor antagonist, attenuates endothelin-1-induced vasoconstriction in rat pulmonary circulation”. J Cardiovasc Pharmacol 22 (1): 39-43. PMID 7690094.

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