Koštani morfogenetički protein 2

(Preusmjereno sa BMP-2)
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Koštani morfogenetički protein 2 ili BMP-2 pripada TGF-β superfamiliji proteina.[1]

Koštani morfogenetički protein 2

PDB prikaz baziran na 3bmp.
Dostupne strukture
1ES7, 1REU, 1REW, 2GOO, 2H62, 2H64, 2QJ9, 2QJA, 2QJB, 3BK3, 3BMP
Identifikatori
SimboliBMP2; BDA2; BMP2A
Vanjski IDOMIM112261 MGI88177 HomoloGene926 GeneCards: BMP2 Gene
Pregled RNK izražavanja
PBB GE BMP2 205289 at tn.png
PBB GE BMP2 205290 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez65012156
EnsemblENSG00000125845ENSMUSG00000027358
UniProtP12643P21274
Ref. Sekv. (iRNK)NM_001200NM_007553
Ref. Sekv. (protein)NP_001191NP_031579
Lokacija (UCSC)Chr 20:
6.75 - 6.76 Mb
Chr 2:
133.55 - 133.56 Mb
PubMed pretraga[1][2]

FunkcijaUredi

BMP-2 poput drugih koštano morfogenetičkih proteina,[2] ima važnu ulogu u razviću kostiju i hrskavice. On učestvuje u hedgehog putu, TGF beta signalnom putu, i interakciji citokina sa citokinskim receptorom. On takođe učestvuje u diferencijaciji srčanih ćelija i epitelijalno mesenhimalnoj tranziciji.

BMP-2 i BMP-7 su osteoinduktivni BMP: demonstrirano je da oni potentno indukuju osteoblastnu diferencijaciju u brojnim tipovima ćelija.[3]

InterakcijeUredi

Koštani morfogenetički protein 2 formira interakcije sa BMPR1A.[4][5][6][7]

ReferenceUredi

  1. Sampath TK, Coughlin JE, Whetstone RM, Banach D, Corbett C, Ridge RJ, Ozkaynak E, Oppermann H, Rueger DC (August 1990). "Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily". J. Biol. Chem. 265 (22): 13198–205. PMID 2376592. 
  2. Chen D, Zhao M, Mundy GR (December 2004). "Bone morphogenetic proteins". Growth Factors 22 (4): 233–41. PMID 15621726. doi:10.1080/08977190412331279890. 
  3. Marie PJ, Debiais F, Haÿ E (2002). "Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling". Histol. Histopathol. 17 (3): 877–85. PMID 12168799. 
  4. Nickel J, Dreyer M K, Kirsch T, Sebald W (2001). "The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists". The Journal of bone and joint surgery. American volume. 83-A Suppl 1 (Pt 1): S7–14. PMID 11263668. 
  5. Kirsch T, Nickel J, Sebald W (February 2000). "Isolation of recombinant BMP receptor IA ectodomain and its 2:1 complex with BMP-2". FEBS Lett. 468 (2-3): 215–9. PMID 10692589. doi:10.1016/S0014-5793(00)01214-X. 
  6. Kirsch T, Nickel J, Sebald W (July 2000). "BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II". EMBO J. 19 (13): 3314–24. PMC 313944. PMID 10880444. doi:10.1093/emboj/19.13.3314. 
  7. Gilboa L, Nohe A, Geissendörfer T, Sebald W, Henis Y I, Knaus P (March 2000). "Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors". Mol. Biol. Cell 11 (3): 1023–35. PMC 14828. PMID 10712517. doi:10.1091/mbc.11.3.1023. 

LiteraturaUredi

  • Nickel J, Dreyer MK, Kirsch T, Sebald W (2001). "The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists.". The Journal of bone and joint surgery. American volume. 83-A Suppl 1 (Pt 1): S7–14. PMID 11263668. 
  • Kawamura C, Kizaki M, Ikeda Y (2003). "Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells.". Leuk. Lymphoma 43 (3): 635–9. PMID 12002771. doi:10.1080/10428190290012182. 
  • Marie PJ, Debiais F, Haÿ E (2003). "Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling.". Histol. Histopathol. 17 (3): 877–85. PMID 12168799. 

Vanjske vezeUredi