B-ciklopiazonat dehidrogenaza
B-ciklopiazonat dehidrogenaza (EC 1.21.99.1, beta-ciklopiazonatna oksidociklaza, beta-ciklopiazonska oksidociklaza, beta-ciklopiazonat:(akceptor) oksidoreduktaza (ciklizacija)) je enzim sa sistematskim imenom beta-ciklopiazonat:akceptor oksidoreduktaza (ciklizacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| B-ciklopiazonat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.21.99.1 | ||||||||
| CAS broj | 9059-00-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- beta-ciklopiazonat + akceptor alfa-ciklopiazonat + redukovani akceptor
Ovaj enzim je flavoprotein (FAD). Citohrom c i razne boje mogu da deluju kao akceptori. Ciklopiazonat je mikrobni toksin.
Reference
uredi- ↑ Edmondson, D.E., Kenney, W.C. and Singer, T.P. (1976). „Structural elucidation and properties of 8α-(N1-histidyl)riboflavin: the flavin component of thiamine dehydrogenase and β-cyclopiazonate oxidocyclase”. Biochemistry 15: 2937-2945. PMID 8076.
- ↑ Schabort, J.C. and Potgieter, D.J.J. (1971). „β-Cyclopiazonate oxidocyclase from Penicillium cyclopium. II. Studies on electron acceptors, inhibitors, enzyme kinetics, amino acid composition, flavin prosthetic group and other properties”. Biochim. Biophys. Acta 250: 329-345. PMID 5143340.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.